Rizikové faktory metabolickéhoestrogen-defi citního syndromu u žen pomenopauze a jejich vztah k hormonálnísubstituční terapii

Risk Factors of Metabolic Estrogen-Defi ciency Syndromand its Relationship to Hormone Replacement Therapy

Objective:
The aim of the study was to review health state in postmenopausal women with long--term hormone replacement therapy and compare it with health state of control group withouthormone replacement therapy. We focused on metabolic estrogen-defi ciency syndrom and its in-fl uence on risk of cardiovascular disease, risk of osteoporosis and memory dysfunction.Design: Epidemiology study.Setting: Department of Obstetrics and Gynecology, University Hospital, Hradec Králové.Methods: Pursuant to clinic and laboratory investigation we evaluated blood pressure, BMI, lipidprofi le, blood sugar, CRP and homocystein in women with EPT, ET and compared the data it withcontrols. Due to dual X-ray absorptiometry we determined bone mineral density and by the memoryquiz we evaluated memory function in examined postmenopausal women.Results: Our results indicate that use of hormone replacement therapy in postmenopausal womenmay be of benefi t in cardiovascular risk factors, especially with better plasma lipid profi le,blood sugar, atherogenity index, BMI and diastolic blood pressure. We found protective role of HTon decrease of bone mineral density in lumbal spine. We didn‘t prove this infl uence in hip. Thereis no evidence of HT infl uence on memory dysfunction, but we found, that culture and social lifeof older women in East Bohemia region is at low level. We did not register any heart attack, strokeand breast cancer under long-term treatment.Conclusion: Women with hormone replacement therapy have less of cardiovascular risk factorsand better status of mineral bone density than women in control group.

Key words:
menopause, hormone replacement therapy, cardiovascular risk factors, osteoporosis