Nukleární faktor kappa B v léčbě zánětlivých a nádorových onemocnění

Nuclear Factor kappa B in the Treatment of Inflammatory and Tumor Diseases

Since its discovery in 1986 nuclear factor kappa B attracted attention of scientists all over the world. Intensiveresearch has proved its indisputable role in pathogenesis of particularly inflammatory and tumor diseases and revealedmany possibilities in the modulation of its function. For some of the modulators distinct therapeutic effects hávebeen proved in in vitro and in vivo studies oř even in the clinical trials, some of them are still to be tested. One mayexpect wide use of different inhibitors oř modulators of nuclear factor kappa B in various indications, which willmarkedly enhance the therapeutic effect

Key words:
apoptosis, nuclear factor kappa B, tumorigenesis, tumors, therapy, inflammation.