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News Overview of the Efficacy of the Fixed Combination Aclidinium-Bromide/Formoterol-Fumarate in the Maintenance Treatment of COPD

Fixed combination inhalation medications have become the cornerstone of pharmacotherapy for moderate to severe chronic obstructive pulmonary disease (COPD). American authors have published an overview of study results evaluating the efficacy and safety of one of the newest fixed combinations of LABA/LAMA, aclidinium-bromide and formoterol-fumarate (AB/FF), in the maintenance treatment of COPD compared to placebo or other medications. These clinical studies investigated the extent to which regular use of this fixed combination alleviates COPD symptoms, improves lung function, reduces the incidence of exacerbations, and increases exercise tolerance.

Source: Treatment of Asthma and COPD 30. 8. 2022

Články časopisu Novel molecules used in the targeted treatment of acute myeloid leukaemia –⁠ adverse reactions, treatment complications and signifi cant drug interactions

Author of the article: J. Vedrová, Z. Ráčil Source: Transfuze a hematologie dnes | 1/2021 15. 3. 2021

News 48 Tablets of Teriflunomide? Nothing Should Be Overdone! −⁠ Case Study

A case study published in the Journal of Clinical Pharmacy and Therapeutics describes an overdose of teriflunomide, specifically the ingestion of 672 mg of this drug. What measures did the doctors take with the patient? And were they able to prevent serious consequences?

Source: Multiple Sclerosis 15. 8. 2023

Články časopisu The EMPRISE study (Real World Evidence): empagliflozin is reducing number of hospitalizations for heart failure, even in patients without cardiovascular disease

Author of the article: Emil Martinka Source: Forum Diabetologicum | 3/2019 18. 12. 2019

Články časopisu Extrahepatic bile duct malignancies

Author of the article: V. Třeška, J. Fichtl, J. Ferda, J. Fínek, T. Skalický, V. Liška, P. Hošek Source: Rozhledy v chirurgii | 9/2022 17. 10. 2022

News Effect of Extended-Release Metformin on Cognitive Functions in Older Frail Women with Diabetes and Hypertension

Women have a higher risk of geriatric frailty regardless of age and menopausal status. This risk further increases with the presence of diabetes and hypertension, which also elevate the risk of cognitive dysfunction. According to available data, metformin may reduce the risk of developing frailty in postmenopausal women. A recently published Italian study, LEOPARDESS, aimed to evaluate the effect of extended-release metformin on the cognitive functions of this population of women.

Source: Cardiovascular Risks 14. 3. 2024

News Inflammation, Polyunsaturated Fatty Acids and Their Significance in the Development and Treatment of Depression

Depression is currently a highly discussed disease with a prevalence that is likely to rise. Therefore, scientists are focusing on potential causes and new treatment modalities. It has been shown that inflammation, which can be influenced by polyunsaturated fatty acids, likely plays a role in the development of the disease. Inflammation is also a possible explanation for the frequent coexistence of depression and metabolic syndrome.

Source: Depression and Anxiety 19. 7. 2020

News Efficacy and Safety of Enoxaparin as Bridging Anticoagulant Therapy After Ventricular Assist Device Implantation

The implantation of a ventricular assist device has become an increasingly common method in the treatment of end-stage heart failure in recent years. The implantation of the device necessitates anticoagulant therapy. In the long term, warfarin is most often used according to guidelines, but there are no clear recommendations for early postoperative anticoagulant therapy. The aim of a clinical study published last year was to evaluate the efficacy and safety of enoxaparin as bridging anticoagulant therapy after device implantation within a 3-month postoperative period.

Source: Thromboprophylaxis 1. 10. 2021

Články časopisu A Rear Cause of Blindness in a Patient with Nasal Polyposis. Leber’s Hereditary Optic Atrophy of Visual Nerve

Author of the article: P. Bruthansová, J. Vokurka, P. Diblík, D. Dočekalová, E. Rozsypalová, J. Zeman, J. Plzák Source: Otorinolaryngologie a foniatrie | 3/2011 6. 10. 2011

News Drops with Liposomal Ozonized Oil Reduce Ocular Microbial Burden Before Cataract Surgery

The periocular zone and conjunctiva are characterized by high microbial activity. Therefore, it is important to reduce this bacterial burden as part of preoperative prophylaxis before surgery to minimize the risk of infection. The aim of the study presented below, conducted in 20 Italian centers, was to evaluate the antimicrobial efficacy of a new ocular solution in patients undergoing cataract surgery.

Source: Treatment of Glaucoma 14. 11. 2023

News Von Willebrand Disease in Women

Even in the context of gynecological issues, it is sometimes necessary to consider a hematological etiology of difficulties. The recommendations of the American College of Obstetricians and Gynecologists (ACOG) in this context focus on the possible connections with von Willebrand disease.

Source: Von Willebrand Disease 23. 11. 2021

News News in COPD Treatment Recommendations in a Nutshell

We present an overview of the most important changes in the annually updated recommendations of the Global Initiative for Chronic Obstructive Lung Disease (GOLD).

Source: Treatment of Asthma and COPD 6. 4. 2022

News Nutritional Care as Part of Prehabilitation in Surgical Patients

Nutritional preparation of patients before surgery as part of prehabilitation can significantly affect the quality of recovery and physical condition of patients after surgery. This topic is highlighted, among other sources, by a team of Canadian doctors in their work published in the journal Anesthesiology, an interesting meta-analysis of 15 RCTs, and last but not least, it is covered in a webinar titled 'Surgical Patient and Nutrition'.

Source: Enteral Nutrition 14. 10. 2020

News Why can probiotics and vitamin D significantly affect human health?

Vitamin D deficiency is the most common hypovitaminosis in developed countries. It is largely related to a lack of outdoor activity. Additionally, the typical Western diet does not support a healthy composition of the gut microbiome. Gut dysbiosis, in turn, is associated with both intestinal and systemic diseases. Alongside a healthy lifestyle, probiotics and oral vitamin D supplementation offer solutions.

Source: GI, colic and microbiome 15. 3. 2022

News Frequent Nausea During Chemotherapy Despite Antiemetic Prophylaxis

Current clinical research has focused on vomiting as a primary issue in the occurrence of CINV (chemotherapy-induced nausea and vomiting) and, using recommended antiemetic prophylaxis, this problem has been relatively well managed. However, the incidence and impact of nausea are underreported. We present the results of an observational study that evaluated the incidence of nausea in patients undergoing chemotherapy.

Source: Antiemetic Therapy 9. 12. 2020