XTANDI (ENZALUTAMIDE): A NEW TREATMENT FOR METASTATIC CASTRATION-RESISTANT PROSTATE CANCER

Czech version

Authors: N. Shore
Published in: Urol List 2013; 11(3): 18-20

Overview

Prostate cancer can return following initial surgical or radiation therapy intervention for localized disease. These men are usually treated with therapies aimed to lower their androgen levels. However, despite these efforts the prostate cancer oftentimes recurs. This recurrence, manifested by a rising PSA, is referred to as castration-resistant prostate cancer. Until recently, few treatment options were available to men with CRPC. Within the last three years, however, several new treatment options for patients with CRPC have become available, including Enzalutamide (XTANDI), the newest therapy approved in May 2012 for the treatment of metastatic CRPC following docetaxel. The author of this article aims to help patients understand how enzalutamide, an androgen receptor inhibitor, was designed and developed as a treatment for patients with CRPC.

Key words:
prostate cancer, castration-resistant, androgen receptor inhibitors

Sources

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5. Scher HI, Fizazi K, Saad F et al for the AFFIRM Investigators. Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy. N Engl J Med 2012; 367: 1187–97.

Labels

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Article was published in

Urological Journal

2013 Issue 3