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CHEMOTHERAPY OF PENILE CARCINOMA


Authors: prim. MUDr. Michaela Matoušková
Authors‘ workplace: Urocentrum Praha
Published in: Urol List 2005; 3(4): 18-20

Overview

Penil carcinoma belongs with its low incidence of less than 0,5% of all male oncological diseases to rare tumours. Phimosis and insufficient hygiene are important risk factors. On the contrary the circumcision in the childhood has proved a protection effect. We prove spinocellular carcinoma in more than 95% of patients. Stage I and II are usually curable by both surgical ablation or organ preserving methods (brachytherapy, laserablation etc). Patients´ survival is dependent on nodal affection (N+). Patients without cli­nically positive nodal affection with infiltrating tumours (> T2), high tumour grading and proved vascular invasion benefit from lymphadenectomy. Lymphadenectomy of palpable nodes usually followed after at least 4-6 weeks of antibiotic therapy. The role of chemotherapy both adjuvant and nonadjuvant, eventually primary in generalized disea­ses, is nowadays evaluated in prospective clinical studies.

KEY WORDS:
penile carcinoma, chemotherapy, spinocellular carcinoma, circumcision


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