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Tixagevimab-cilgavimab eff ectiveness in preexposure prophylaxis and therapy in patients at high risk of COVID-19


Authors: B. Weinbergerová;  T. Kabut;  J. Mayer
Authors‘ workplace: Interní hematologická a onkologická klinika LF MU a FN Brno
Published in: Transfuze Hematol. dnes,28, 2022, No. 4, p. 195-201.
Category: Review/Educational Papers
doi: https://doi.org/10.48095/cctahd2022prolekare.cz14

Overview

COVID-19 caused by SARS-CoV-2 is a life-threatening global pandemic disease that has led to high mortality for over two years. Elderly individuals with comorbidities and immunocompromised patients are particularly at risk. Scientifi c research eff orts are therefore intensively focused on the development and optimization of COVID-19 treatment. Early treatment with SARS-CoV-2-neutralizing monoclonal antibodies has been shown to be eff ective both in vitro and in clinical practice in patients at high risk of disease progression to severe COVID-19. This paper summarizes the potential clinical benefi ts of the recently approved monoclonal antibody combination tixagevimab and cilgavimab for COVID-19 prevention and treatment.

Keywords:

vaccination – Monoclonal antibodies – therapy – COVID-19 – tixagevimab – cilgavimab – preexposure prophylaxis – immunocompromised haematological patient


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