Blood cell analysers – signifi cance of a dimorphic red blood cell population
Authors:
E. Pešková 1; I. Fátorová 1; K. Hrnčířová 1; D. Rydvalová 1; L. Smolej 1,2; F. Vrbacký 1
Authors‘ workplace:
IV. interní hematologická klinika FN Hradec Králové
1; LF UK, Hradec Králové
2
Published in:
Transfuze Hematol. dnes,27, 2021, No. 1, p. 51-56.
Category:
Original Papers
doi:
https://doi.org/10.48095/cctahd202151
Overview
The dimorphic red blood cell (RBC) population flag is caused by an abnormal red blood cell distribution curve due to the presence of more than one population of red blood cells in a given sample. The mean corpuscular volume (MCV) parameter does not correspond to the real size of the red blood cells in such cases. The red cell distribution width (RDW) parameter is either unreliable or it is not provided by the analyser at all. The dimorphic red blood cell population flag can be raised by samples with extremely high lymphocyte or macrothrombocyte counts. In these cases, it is caused by interference with the electrical impedance method for measuring RBC, not by the presence of several RBC populations.
Keywords:
dimorphic red cells – histogram – red blood cell distribution width – mean corpuscular volume
Sources
1. Constantino BT. The red cell histogram and the dimorphic red cell population. Lab Med. 2011; 42 (5): 300–308.
2. J. Bras. Evaluation of RDW-CV, RDW-SD, and MATH-1SD for the detection of erythrocyte anisocytosis observed by optical microscopy. J Brasil Patol Med Labor. 2013; 49 (5): 324-331.
3. https: //www.sysmex.cz/vzdelavani/technologie/technologie-mereni/hydrodynamicka-fokusace.html
4. Münster M. The red blood cell indices. Sysmex Educational Enhancement and Development. October 2012. https: //www.sysmex-europe.com/fileadmin/media/f100/SEED/Sysmex_SEED_The_Red_Blood_Cell_Indices.pdf
5. Sarma PR. Red cell indices. In: Walker HK, Hall WD, Hurst JW, editors. Clinical methods: the history, physical, and laboratory examination. 3rd edition. Boston, Butterworths, 1990; 720-723.
6. http: //www.med-health.net/Rdw-Cv-And-Rdw-Sd.html
7. https: //www.labce.com/spg579125_ interpretation
8. Thomas ETA, Bhagya S, Majere A. Clinical utility of blood cell histogram interpretation. J Clin Diagn Res. 2017; 11 (9): OE01–OE04.
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2021 Issue 1
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