Chronic lymphocytic leukaemia – contemporary application of modern prognostic and predictive markers in diagnostics

Czech version

Authors: Š. Pospíšilová ^1,2; M. Jarošová ^1,2; M. Doubek ^1,2
Authors‘ workplace: Interní hematologická a onkologická klinika LF MU a FN Brno ¹; Centrum molekulární medicíny, CEITEC, Masarykova univerzita, Brno ²
Published in: Transfuze Hematol. dnes,25, 2019, No. 1, p. 66-71.
Category: Review/Educational Papers

Overview

Insights into the biology and pathogenesis of chronic lymphocytic leukaemia (CLL) have dramatically increased over the past 25 years. Treatment of this disease has also dramatically changed. This is an example of one of the most striking advances in the entire field of oncological haematology. CLL has a very heterogeneous clinical outcome depending on many factors. Prognostic markers thus play an important role in disease management and assist in the selection of the best treatment option. The key prognostic and predictive factors influencing treatment decisions are TP53 gene aberrations, especially in the era of novel therapies. The introduction of high-throughput genomic approaches has led to the identification of novel genetic abnormalities that could contribute to improved risk stratification of CLL patients and also enable tracking of leukemic clone(s) evolution.

Keywords:

chronic lymphocytic leukaemia – prognostic factors – predictive factors – Cytogenetics – TP53 – IGHV

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