Invasive fungal infections following autologous hematopoietic stem cell transplantation in patients with multiple myeloma

Czech version

Authors: J. Gabzdilová; E. Tóthová ¹; T. Guman ²; Š. Raffač ¹; P. Jarčuška ^{3 4}
Authors‘ workplace: Klinika hematológie a onkohematológie UNLP a LF UPJŠ, Košice ¹; Ústav lekárskej a klinickej biofyziky LF UPJŠ, Košice ²; Oddelenie laboratórnej medicíny UNLP, Košice ³; Klinika infektológie a cestovnej medicíny UNLP a LF UPJŠ, Košice ⁴
Published in: Transfuze Hematol. dnes,21, 2015, No. 1, p. 24-29.
Category: Comprehensive Reports, Original Papers, Case Reports

Overview

The article gives a history of the occurrence of invasive fungal infections in patients with multiple myeloma following autologous stem cell transplantation. These patients are at low risk (LR) for developing invasive fungal infection (IFI). It assesses the impact of previous treatment of the underlying disease; comorbidities and risk factors for the incidence and aetiology of invasive fungal infections; their clinical manifestation and treatment. In the analysed group of 39 patients, invasive fungal infection developed in 4 patients. In 2 cases, possible invasive fungal infection of the lungs was diagnosed One patient was diagnosed with probable invasive aspergillosis of the lungs and the other case suggested the possibility of lung infection caused by Trichosporon species. Risks associated with the development of these infectious complications included the administration of corticosteroids, neutropenia, mucositis and renal insufficiency.

Key words:
multiple myeloma, invasive fungal infections, risk factors, autologous hematopoietic stem cell transplantation

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