Global assessment of haemostatic function - part II. Our experience with thrombin generation test using in thrombophilia patients
Authors:
A. Hluší 1; L. Slavík 1; J. Úlehlová 1; V. Krčová 1; J. Zapletalová 1; K. Indrák 1
Authors‘ workplace:
Hemato-onkologická klinika FN LF UP Olomouc, 2Ústav lékařské biofyziky, pracoviště biometrie
Lékařská fakulta UP Olomouc
1
Published in:
Transfuze Hematol. dnes,16, 2010, No. 3, p. 121-125.
Category:
Comprehensive Reports, Original Papers, Case Reports
Overview
Generally used haemostatic tests do not cover the complexity of clotting system. Estimation of the potential to generate thrombin, which is the central enzyme in the blood coagulation, may correlate with thrombophilic fenotype. In our study we used thrombin generation test to evaluate the parameters of thrombin generation curve in thrombophilic patients and healthy blood donors groups. We compare results in asymptomatic and symptomatic subgroups of thrombophilic mutation carriers and also an influence of acquired risk factor on thrombin generation is assessed. The results show higher generation of thrombin in carriers of thrombophilic mutation which is statistically significant.
Key words:
thrombophilia, thrombin generation test, acquired risk factors
Sources
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Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2010 Issue 3
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