Transplantation neural stemcells and hematopoiesis reparation
Authors:
S. Filip 1; J. Mokrý 2; J. Karbanová 2; J. Vávrová 3; J. Vokurková 4
Authors‘ workplace:
Onkologická a radioterapeutická klinika FN, Hradec Králové 2Katedra histologie a embryologie LF UK, Hradec Králové 3Ústav imunologie a radiobiologie VLA JEP, Hradec Králové 4Odd. klinické imunologie FN, Hradec Králové
1
Published in:
Transfuze Hematol. dnes,, 2003, No. 4, p. 178-180.
Category:
Overview
Stem cells for their unique property - plasticity promise a universal utilization,mainly, in the reparationof most organs and tissues in the human body. In this communication, the authors presents theirexperimental results in a model of neural stem cells (NCSc) where the main goal was to preserve theNSCs hemopoietic identity. Mice given whole body sublethal irradiation with a dose of LD 8.5 Gy weresaved by transplantation of labelled (X-Gal+) NSCs. The demonstration of increased uptake of NSCs inthe spleen led us to study the relationship of hemopoietic microenvironment and hemopoietic identity.The proof of hemopoeitic identity was performed by cultivation of CFU-GM from the bone marrow -where cells exhibiting X-Gal positivity were identified by histochemistry. Our experiments showdifferent ways how NSCs transplantation may influence the damaged hematopoiesis.
Key words:
stem cells, transplantation, hematopoiesis, cell therapy
Labels
Haematology Internal medicine Clinical oncologyArticle was published in
Transfusion and Haematology Today
2003 Issue 4
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