Choline significance in nutritional supplementation in pregnant women
Authors:
Adéla Faridová
Authors‘ workplace:
Ústav pro péči o matku a dítě Praha
Published in:
Prakt Gyn 2016; 20(1): 53-57
Category:
Overview
Maternal diet during pregnancy and lactation is the simplest prevention for fetal development. Adequate intake of choline decreases the risk of birth defects, protects from undesirable exposure of the fetus to alcohol and has potential effects on hippocampal neurogenesis and memory function. Choline is one of the major source of methyl groups and very important component of epigenetic mechanism. Meat, milk and eggs contain enough choline. For women who do not eat vegetarian diet, a supplement should be considered.
Keywords:
choline – DNA methylation – epigenetics – maternal diet – vegetarianism
Sources
1. Chango A, Pogribny IP. Considering Maternal Dietary Modulators for Epigenetic Regulation and Programming of the Fetal Epigenome. Nutrients 2015; 7(4): 2748–2770.
2. Sharma S, KellyTK, Jones PA. Epigenetics in cancer. Carcinogenesis 2010; 31: 27–36.
3. Das R, Dimitrova N, Xuan Z et al. Computational prediction of methylation status in human genomic sequences. Proc Natl Acad Sci USA 2006; 103(28): 10713–10716.
4. Waterland RA. Assessing the effects of high methionine intake on DNA methylation. J Nutr 2006; 136(6 Suppl): S1706–S1710.
5. Tucker KL, Smith CE, Lai CHQ et al. Quantifying Diet for Nutrigenomic Studies. Annu Rev Nutr 2013; 33: 349–371.
6. Zeisel SH. Nutrition in pregnancy: the argument for including a source of choline. Int J Womens Health 2013; 5: 193–199.
7. Zeisel SH. Choline: critical role during fetal development and dietary requirements in adults. Annu Rev Nutr 2006; 26: 229–250.
8. Burg M. Molecular basis of osmotic regulation. Am J Physiol 1995; 268(6 Pt 2): F983-F996.
9. Cohen EL, Wurtman RJ. Brain acetylcholine: control by dietary choline. Science 1976; 191(4227): 561–562.
10. Shaw GM, Carmichael SL, Yang W et al. Periconceptional dietary intake of choline and betaine and neural tube defects in offspring. Am J Epidemiol 2004; 160(2): 102–109.
11. Shaw GM, Carmichael SL, Laurent C et al. Maternal nutrient intakes and risk of orofacial clefts. Epidemiology 2006; 17(3): 285–291.
12. Tang N, Bamford P, Jones J et al. Choline partially prevents the impact of ethanol on the lipid raft dependent functions of l1 cell adhesion molecule. Alcohol Clin Exp Res 2014; 38(11): 2722–2730.
13. Hoyme HE, May PA, Kalberg WO et al. A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria. Pediatrics 2005; 115(1): 39–47.
14. Thomas JD, Abou EJ, Dominguez HD. Prenatal choline supplementation mitigates the adverse effects of prenatal alcohol exposure on development in rats. Neurotoxicol Teratol 2009; 31(5): 303–311.
15. Tomizawa H, Matsuzawa D, Ishii D et al. Methyl-donor deficiency in adolescence affects memory and epigenetic status in the mouse hippocampus. Genes Brain Behav 2015; 14(3): 301–309.
16. Pyapali GK, Turner DA, Williams CL et al. Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. J Neurophysiol 1998; 79(4): 1790–1796.
17. Poly C, Massaro JM, Seshadri S et al. The relation of dietary choline to cognitive performance and white-matter hyperintensity in the Framingham Offspring Cohort. Am J Clin Nutr 2011; 94(6): 1584–1591.
18. Cheatham CL, Goldman BD, Fischer LM et al. Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2012; 96(6): 1465–1472.
19. Jiang X, Bar HY, Yan J et al. A higher maternal choline intake among third-trimester pregnant women lowers placental and circulating concentrations of the antiangiogenic factor fms-like tyrosine kinase-1 (sFLT1). FASEB J 2013; 27(3): 1245–1253.
20. Jiang X, Yan J, West AA et al. Maternal choline intake alters the epigenetic state of fetal cortisol-regulating genes in humans. FASEB J 2012; 26(8): 3563–3574.
21. Bremer J, Figard PH, Greenberg DM. The biosynthesis of choline and its relation to phospholipid metabolism. Biochim Biophys Acta 1960; 43: 477–488.
22. United States Department of Agriculture. USDA Database for the Choline Content of Common Foods, Release 2. 2008. Dostupné z WWW: <http://www.ars.usda.gov/SP2UserFiles/Place/80400525/Data/Choline/Choln02.pdf>.
23. Cho E, Zeisel SH, Jacques P et al. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr 2006; 83(4): 905–911.
24. Institute of Medicine, National Academy of Sciences USA. Dietary Reference Intakes for Folate, Thiamin, Riboflavin, Niacin, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academy Press: Washington (DC) 1998. Choline: 390–422.
25. Resseguie M, Song J, Niculescu MD et al. Phosphatidylethanolamine N-methyltransferase (PEMT) gene expression is induced by estrogen in human and mouse primary hepatocytes. FASEB J 2007; 21(10): 2622–2632.
26. Zeisel SH, Epstein MF, Wurtman RJ. Elevated choline concentration in neonatal plasma. Life Sci 1980; 26(21): 1827–1831.
27. Fischer LM, da Costa KA, Galanko J et al. Choline intake and genetic polymorphisms influence choline metabolite concentrations in human breast milk and plasma. Am J Clin Nutr 2010; 92(2): 336–346.
28. Yan J, Jiang X, West AA et al. Maternal choline intake modulates maternal and fetal biomarkers of choline metabolism in humans. Am J Clin Nutr 2012; 95(5): 1060–1071.
29. Cao D, Kevala K, Kim J et al. Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function. J Neurochem 2009; 111(2): 510–521.
30. Fischer LM, daCosta KA, Kwock L et al. Sex and menopausal status influence human dietary requirements for the nutrient choline. Am J Clin Nutr 2007; 85(5): 1275–1285.
31. Sha W, da Costa KA, Fischer LM et al. Metabolomic profiling can predict which humans will develop liver dysfunction when deprived of dietary choline. FASEB J 2010; 24(8): 2962–2975.
32. Resseguie ME, da Costa KA, Galanko JA et al. Aberrant estrogen regulation of PEMT results in choline deficiency-associated liver dysfunction. J Biol Chem 2011; 286(2): 1649–1658.
33. Zeisel SH, Mar MH, Howe JC et al. Concentrations of choline-containing compounds and betaine in common foods. J Nutr 2003; 133(5): 1302–1307.
34. Lee WJ, Weng SH, Su NW. Individual Phosphatidylcholine Species Analysis by RP-HPLC-ELSD for Determination of Polyenylphosphatidylcholine in Lecithins. J Agric Food Chem 2015 ; 63(15): 3851–3858.
35. Zeisel SH, Wishnok JS, Blusztajn JK. Formation of methylamines from ingested choline and lecithin. J Pharmacol Exp Ther 1983; 225(2): 320–324.
36. Romano KA, Vivas EI, Amador-Noguez et al. Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide. MBio 2015; 6(2): e02481. Dostupné z DOI: <http://dx.doi.org/10.1128/mBio.02481–14>.
37. Wang Z, Klipfell E, Bennett BJ et al. Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature 2011; 472(7341): 57–63.
38. Cheatham CL, Goldman BD, Fischer LM et al. Phosphatidylcholine supplementation in pregnant women consuming moderate-choline diets does not enhance infant cognitive function: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 2012; 96(6): 1465–1472.
39. Cullum-Dugan D, Pawlak R. Position of the academy of nutrition and dietetics: vegetarian diets. J Acad Nutr Diet 2015; 115(5): 801–810.
40. O’Neill RJ, Vrana PB, Rosenfeld CS. Maternal methyl supplemented diets and effects on offspring health. Front Genet 2014; 5: 289. Dostupné z DOI: <http://10.3389/fgene.2014.00289>.
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Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Practical Gynecology
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