The influence of tibolonee on fibrocystic changes in the mammary gland
Authors:
L. Večeřová; J. Vachoušek; V. Smejkal
Authors‘ workplace:
Centrum pro nemoci prsu, Praha
Published in:
Prakt Gyn 2007; 11(2): 82-86
Overview
Objective:
Assessment of changes in the ultrasonographic image of the mammary gland in postmenopausal women with fibro-cystic transformation taking tibolone instead of hormone substitution therapy; a prospective non-randomised study.
Material and method:
Fifty postmenopausal women with mammographically and ultrasonographically proven fibrocystic transformation of the mammary gland were included in the prospective, non-randomised study. The women were divided into 2 groups based on acute climacteric syndrome and the resulting wish to take hormonal substitution therapy. The 1st group included women (n = 30) who wished to take tibolone (Livial® Organon) or to continue taking the drug after a 1 to 12 month experience. The 2nd group included women (n = 20) who did not wish and did not take hormonal therapy. Changes in the ultrasound image were monitored in both the groups at 3, 6 and 12 month intervals from the start of study. The results were statistically evaluated using the pair t-test.
Results:
Significant decrease (p < 0.0001) in the diameter of simplex cysts from 12.42 ± 1.4 mm to 8.3 ± 2.18 mm was recorded during one year follow up in women taking tibolone. The size of simplex cysts remained unchanged in the control group of women without therapy.
Conclusion:
The study has shown statistically significant reduction in the diameter of simplex cysts in the area of fibrocystic transformation of the mammary gland in women taking tibolone versus the group of women without treatment. The above results correspond to data in literature on the subject and provide further evidence for the theory of selective regulation of tissue estrogenic activity by tibolone.
Key words:
tibolone – hormone substitution therapy – ultrasonographic breast examination – fibrocystic breast transformation
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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Practical Gynecology
2007 Issue 2
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