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The influence of hormonal contraception on multiple cerebrospinal sclerosis


Authors: Peter Koliba;  M. Petzel
Authors‘ workplace: Porodnicko-gynekologická klinika FNsP Ostrava
Published in: Prakt Gyn 2005; 9(3): 20-21

Overview

The authors in their work deal with the relationship between multiple cerebrospinal sclerosis (MS) and hormonal contraception. Since MS affects the women in productive age, this issue is highly topical. The influence of hormonal factors on the course of MS is known, although its mechanism is only mediated by the influence on immune system. The authors also present the published possible interaction of drugs used at MS with hormonal contraception and they state that the negative influence of hormonal contraception on MS has not been proved.

Key words:
multiple cerebrospinal sclerosis – hormonal contraception – estrogens – drugs interaction – family planning


Sources

1. Pugliatti M, Sotgiu S, Rosami G. The worldwide prevalence of multiple sclerosis. Clin Neurosurg 2002; 104: 182.

2. Archelos J, Storch MK, Hartung HP. Pathogenic role of antibodies in neurological diseass. Trends Neurosci 2000; 23: 317-327.

3. Archellos JJ, Storch MK, Hartung HP. The role of B cells and autoantibodies in multiple sclerosis. Amm Neurol 2000; 47: 694-706.

4. Martin R, Mc Farland HF, Mc Farlin DE. Immunological aspects of demyelinating disease. Annu Rev Imunnol 1992; 142: 771-776.

5. Genain CP, Capella B, Hauser SL, Raine CS. Identification of autoantibodies associated with myelin damage in multiple sclerosis. Nat medicine 1999; 5: 170-175.

6. Lehmann PV, Sercarz EE, Forsthuber T et al. Determinating spreading and the dynamics of the autoimmune T-cell repertoáre. Immunol Today 1993; 14: 203-208.

7. Vanderlugt CL, Miller SD. Epitope spreading in immune – mediated diseases: imlications for immunotherapy. Nat Rev Immunol 2002; 2: 85-95.

8. Genain CP, Canella B, Hauser SL, Raine CS. Identification of antibodies assotiated with myelin damage in multiple sclerosis. Nat Med 1999; 5: 170-175.

9. Reindl M, Linington C, Brehm U et al. Antibodies against the myelin oligodendrocyte glycoprotein and the myelin basic protein in multiple sclerosis and other neurological diseases: a comparative study. Brain 1999; 122: 2047-2056.

10. Bielekova B, Goodwin B, Richert N et al. Encephalitogenc potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: result of phase II clinical trial with an altered peptide ligand. Nat Med 2000; 6: 1167-1175.

11. Roullet E, Verdier-Taileffer MH, Amarenco P. Pregnancy and multiple sclerosis: a longitudinal study of 125 remitting patiens. J Neurol Neurosurgery Psychiatry 1993; 56: 1062-1065.

12. Sadovnick AD, Eisen K, Hashimoto SA et al. Pregnancy and multiple sclerosis. A prospective study. Arch Neurol 1994; 51: 1120-1124.

13. Tilmann AJB. The effect of pregnancy on multiple sclerosis and its management. Proc Assoc Res Nerv Ment Dis 1950; 28: 548-582.

14. Trooster WJ, Teelken AW, Kampinga J, Loof JG. Supression of acute experimental allergic encephalomyelitis by the synthetic sex hormone 17 – sloha ethinylestradiole: An immunological study in the Lewis rat. Int Arch Allergy Immunol 1993; 102: 133-140.

15. Trooster WJ, Teelken AW, Kampinga J, Loof JG, Nieuwenhuis P. The effect of gonadectomy on the clinical course of chronic experimental allergic encephalomyelitis. Clinical Neurol Neurosurg 1996; 98: 222-226.

16. Villard-Macintosh L, Vessey MP. Oral contraceptives and reproductive factors in multiple sclerosis incidence Contraception 1993; 47: 161-168.

17. Thorogood M, Hannaford PC. The influence of oral contraceptives and the risk of multiple sclerosis. Br J Obstet Gyn 1998; 105: 1296-1299.

18. Hernánn MA, Hohol MJ, Olek MJ, Piegelmann D, Ascherio A. Oral contraceptives and the incidence of multiple sclerosis. Neurology 2000; 111: 77-85.

19. Zapletalová O, Hradílek P, Doležil D, Koliba P, Woznicová I. The effect of pregnancy and delivery/abortion in the course of multiple sclerosis. European Journal of Neurology 2004; 11(Suppl 2): XXX-XXX.

Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicine
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