Developmental defects in reproduction losses in the 1st trimester of pregnancy
Authors:
prof. RNDr. Ján Vojtaššák, CSc. 1; RNDr. Jana Malová, Ph.D. 1; MUDr. Ľudmila Demjénová 1; doc. MUDr. Miroslav Korbeľ, CSc. 2; MUDr. Peter Martanovič 3
Authors‘ workplace:
Ústav lekárskej biológie a genetiky Lekárskej fakulty UK v Bratislave
1; I. gynekologicko-pôrodnícka klinika Lekárskej fakulty UK v Bratislave
2; Ústav patologickej anatómie Lekárskej fakulty UK v Bratislave
3
Published in:
Prakt Gyn 2005; 9(2): 15-18
Overview
Early reproduction losses represent a part of prenatal selection system, which provides elimination of individuals with disturbed embryonal development. 1 829 spontaneous abortion of the 1st trimester of pregnancy from the region of Bratislava were cytogenetically and morphologically analyzed in the presented study. Severe disturbance of embryogenesis, almost in a half (45%) of informative analyzed cases were detected. At further 14% of cases milder development defects were detected and they could be considered the equivalent of inborn developmental defects. High frequency of chromosomal aberrations, predominantly trisomies, which represents a new gametic mutations, were detected. Information regarding the cause of the reproduction loss may increase the probability of successful termination of the next pregnancy.
Key words:
early reproduction losses — disturbance of embryogenesis — inborn developmental defects — chromosomal aberrations
Sources
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Labels
Paediatric gynaecology Gynaecology and obstetrics Reproduction medicineArticle was published in
Practical Gynecology
2005 Issue 2
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