Breast cancer localization by iodine seed 125I vs. wire- -guided localization – retrospective case-control study

Czech version

Authors: J. Žatecký ^1,2; Z. Heralt ¹; D. Sekret ¹; E. Sehnálková ^2,3; M. Peteja ^1,2
Authors‘ workplace: Chirurgické oddělení, Slezská nemocnice, v Opavě, p. o. ¹; Ústav nelékařských, zdravotnických studií, Fakulta veřejných politik, SU v Opavě ²; Oddělení patologie, Slezská nemocnice, v Opavě, p. o. ³
Published in: Rozhl. Chir., 2024, roč. 103, č. 7, s. 263-268.
Category: Original articles
doi: https://doi.org/10.48095/ccrvch2024263

Overview

Introduction: For many years, the gold standard in the localization of non-palpable malignant breast tumors has been the use of wire-guided method. However, this has recently been replaced by more modern localization techniques in many institutions. Methods: This is a retrospective case-control study comparing two localization techniques (iodine seed 125I and wire-guided localization) for localizing non-palpable tumors in patients with histologically verified breast carcinoma.

Results: The study included 62 patients – 31 with localization of malignant breast tumor by iodine seed (subgroup 125I) and 31 by wire-guided localization (subgroup FV). The average volume of the resected tissue in subgroup 125I (46.2 cm3) was statistically significantly smaller compared to subgroup FV (83.7 cm3; P = 0.0063). R0 resection was achieved in 29 cases (93.5%) in subgroup 125I and in 24 cases (77.4%) in subgroup FV (P = 0.0714). In subgroup 125I, re-resection was not indicated in any case, while in subgroup FV, re-resection due to tumor reaching the margin was indicated in 6 cases (19.4%; P = 0.01).

Conclusion: Our initial experience show that the use of iodine seeds for localizing non-palpable breast tumors is associated with the removal of a smaller volume of resected tissue compared to wire-guided localization, with a trend towards more frequent achievement of R0 resection. In the subgroup of patients localized with iodine seeds, there was a smaller proportion of re-resections due to inadequate safety margins.

Keywords:

breast cancer – localizations techniques – iodine seed – wire-guided localization

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MUDr. Jan Žatecký, Ph.D.

Chirurgické oddělení

Slezská nemocnice v Opavě, p.o. Olomoucká 470/86

746 01 Opava jan.zatecky@snopava.cz

ORCID autorů

J. Žatecký ORCID 0000-0002-0415-0853

M. Peteja ORCID 0000-0002-3885-1025