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Our experience with solitary fibrous tumors in the chest area


Authors: J. Muri 1;  B. Durcová 2;  M. Ledecký 3;  V. Kamarád 1;  M. Makovická 1;  A. Vrbenská 4
Authors‘ workplace: Ústav histologie a embryologie Lékařská fakulta Ostravská univerzita, Ostrava 1;  2. Oddelenie pneumológie a ftizeológie NÚTPCHaHCH Vyšné Hágy, Vysoké Tatry 2;  Oddelenie srdcovej a cievnej chirurgie KCE AGEL Košice 3;  Oddelenie patológie NÚTPCHaHCH Vyšné Hágy, Vysoké Tatry 4
Published in: Rozhl. Chir., 2023, roč. 102, č. 3, s. 134-138.
Category: Case Report
doi: https://doi.org/10.33699/PIS.2023.102.3.134–138

Overview

The article reports on three patients with a solitary fibrous tumor of the chest. The first patient had a tumor in the area of the dome of the right pleural cavity which was radically resected together with the chest wall around its origin. In the second case, the tumor was attached by a vascular pedicle to the lower lobe of the right lung. This tumor was resected atypically, via thoracotomy, along with a margin of healthy lung tissue at the base of its pedicle. The last patient had a tumor of the lower lobe of the right lung, surrounding the lower pulmonary vein, which did not have a clear margin of healthy lung tissue. This finding required right lower lobectomy via posterolateral thoracotomy.

The presented cases describe rare types of tumors in the chest area which at the time of detection often reach large dimensions, necessitating extensive surgical procedures. Due to the biological nature of these tumors, long-term patient follow-up is advisable.

Keywords:

Thoracotomy – solitary fibrous tumor – lung lobectomy


Sources

1. Klemperer P, Coleman BR. Primary neoplasms of the pleura. A report of five cases. Am J Ind Med. 1992;22(1):1−31. doi: 10.1002/ajim.4700220103.

2. Davanzo B, Emerson RE, Lisy M, et al. Solitary fibrous tumor. Transl Gastroenterol Hepatol. 2018;3:94. doi: 10.21037/ tgh.2018.11.02.

3. Gold JS, Antonescu CR, Hajdu C, et al. Clinicopathologic correlates of solitary fibrous tumors. Cancer 2002; 94(4):1057−1068.

4. Toporcer T, Belák J, Böör A, et al. Obrovský solitárny fibrózny tumor pleury – kazuistika. Rozhl Chir. 2009;88(3):97−102.

5. Demicco EG, Park MS, Araujo DM, et al. Solitary fibrous tumor: a clinicopathological study of 110 cases and proposed risk assessment model. Mod Pathol. 2012;25(9):1298−1306. doi: 10.1038/ modpathol.2012.83. Epub 2012 May 11.

6. Martin-Broto J, Mondaza-Hernandez JL, Moura DS, et al. A comprehensive review on solitary fibrous tumor: New insights for new horizons. Cancers (Basel) 2021;13(12):2913. doi: 10.3390/cancers13122913. PMID: 34200924; PMCID: PMC8230482.

7. Pavlíková P, Sochorová L, Snížková O, et al. Solitary fibrous tumor of the pleura as a rare cause of severe hypoglycemia: Doege-Potter syndrome. Rozhl Chir. 2020;99(2):95−98. doi: 10.33699/ PIS.2020.99.2.95-98.

8. Yokoi T, Tsuzuki T, Yatabe Y, et al. Solitary fibrous tumour: significance of p53 and CD34 immunoreactivity in its malignant transformation. Histopathology 1998 May;32(5):423−432. doi: 10.1046/j.1365- 2559.1998.00412.x.

9. Robinson DR, Wu YM, Kalyana-Sundaram S, et al. Identification of recurrent NAB2- STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. Nat Genet. 2013 Feb;45(2):180−185. doi: 10.1038/ ng.2509. Epub 2013 Jan 13.

10. Krsková L, Odintsov I, Fabián O, et al. Determination of biological behavior of solitary fibrous tumors: correlation of expression of Ki-67, TPX2 and TERT mRNA subunit level and NAB2-STAT6 fusion compared to morphological aspects of SFTs. Neoplasma 2022 Jan;69(1):28−35. doi: 10.4149/neo_2021_210511N642. Epub 2021 Nov 25.

11. Thway K, Flora R, Shah C, et al. Diagnostic utility of p16, CDK4, and MDM2 as an immunohistochemical panel in distinguishing well-differentiated and dedifferentiated liposarcomas from other adipocytic tumors. Am J Surg Pathol. 2012 Mar;36(3):462−469. doi: 10.1097/ PAS.0b013e3182417330.

12. Geramizadeh B, Marzban M, Churg A. Role of immunohistochemistry in the diagnosis of solitary fibrous tumor, a review. Iran J Pathol. 2016;11(3):195−203.

13. Vejvodova S, Spidlen V, Mukensnabl P, et al. Solitary fibrous tumor − less common neoplasms of the pleural cavity. Ann Thorac Cardiovasc Surg. 2017 Feb 20;23(1):12−18. doi: 10.5761/atcs.oa.16- 00108. Epub 2016 Dec 28.

14. Szkorupa M, Klein J, Bohanes T, et al. Solitární fibrózní tumor pleurální dutiny. Rozhl Chir. 2010 Dec;89(12):750−753.

15. Hatooka S, Shigematsu Y, Nakanishi M, et l. Subxiphoid approach for extracting a giant solitary fibrous tumour of the pleura. Interact Cardiovasc Thorac Surg. 2017 Nov 1;25(5):834−835. doi: 10.1093/ icvts/ivx134.

16. Ozaniak A, Hladik P, Lischke R, et al. Diagnostic challenges and treatment options in patients with solitary fibrous tumor: A single-center observational study. Front Surg. 2022;9:952463. Published 2022 Aug 31. doi:10.3389/ fsurg.2022.952463

17. Boothe JT, Budd GT, Smolkin MB, et al. Durable near-complete response to anti- PD-1 checkpoint immunotherapy in a refractory malignant solitary fibrous tumor of the pleura. Case Rep Oncol. 2017 Nov 13;10(3):998−1005. doi: 10.1159/000484041.

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