Repeated surgery for parathyroid carcinoma
Authors:
P. Libánský 1; J. Tvrdoň 1; P. Broulík 2; J. Kubinyi 3; M. Fialová 1; S. Adámek 1; R. Lischke 1
Authors‘ workplace:
III. chirurgická klinika 1. LF UK a FN Motol Praha, přednosta: Prof. MUDr. R. Lischke, Ph. D.
1; III. interní klinika 1. LF UK a VFN Praha, přednosta: Prof. MUDr. Š. Svačina, DrSc., MBA
2; Ústav nukleární medicíny 1. LF UK a VFN Praha, přednosta: Prof. MUDr. M. Šámal, DrSc.
3
Published in:
Rozhl. Chir., 2012, roč. 91, č. 11, s. 601-607.
Category:
Original articles
Overview
Introduction:
Carcinoma of the parathyroid glands is a rare cause of primary hyperparathyroidism with an incidence of 1%.
Material and methods:
This article presents an up-to-date review of the literature illustrated by three clinical cases in the form of case reports.
Results:
Parathyroid carcinoma is usually not detected before the first operation. Symptoms of carcinoma of the parathyroid glands are similar to those of benign adenoma. Patients with parathyroid carcinoma usually have a higher level of calcium in serum and a higher level of parathormone. Imaging methods such as neck ultrasound and 99mTc sestamibi scan can help localize pathologically enlarged glands, but they are not capable of distinguishing malignant disease. Fine needle aspiration is not recommended due to the possible associated risk of tumour seeding along the needle track. The radical excision of the tumour together with the ipsilateral thyroid gland removal remains the standard of treatment. Local recurrence is frequent.
Conclusion:
Parathyroid carcinoma is a very rare disease and should be managed surgically in a specialized centre.
Keywords:
Primary hyperparathyroidism – parathyroidectomy – parathyroid carcinoma
Sources
1. Wang CA, Gaz RD. Natural history of parathyroid carcinoma. Diagnosis, treatment, and results. Am J Surg 1985;149(4):522–7.
2. Sandelin K, Thompson NW, Bondeson L. Metastatic parathyroid carcinoma: dilemmas in management. Surgery 1991;110(6): 978–86; discussion 986–8.
3. Jakoubková S, Vokurka J, Čáp, J, Ryska A. Parathyroid carcinoma: Clinical presentation and treatment. International Congress Series 2003;1240:991–5.
4. Linhartová M, Starý K. Karcinom příštítného tělíska – současný pohled. In Sborník abstrakt XXXII. Endokrinologické dny s mezinárodní účastí. Český Krumlov 2009:50.
5. Sandelin K. Parathyroid carcinoma in Clark O, Duh Q. Textbook of endocrine surgery. Philadelphia, W.B. Saunders 1997:277–283.
6. Hundahl SA, Fleming ID, Fremgen AM, Menck HR. Two hundred eighty-six cases of parathyroid carcinoma treated in the U.S. between 1985-1995: a National Cancer Data Base Report. The American College of Surgeons Commission on Cancer and the American Cancer Society Cancer 1999;86(3):538–44.
7. Kassahun WT, Jonas S. Focus on parathyroid carcinoma. Int J Surg 2011;9(1):13–9. Epub 2010 Sep 30. Review.
8. Carpten JD, Robbins CM, Villablanca A, Forsberg L, Presciuttini S, Bailey-Wilson J, Simonds WF, Gillanders EM, Kennedy AM, Chen JD, Agarwal SK, Sood R, Jones MP, Moses TY, Haven C, Petillo D, Leotlela PD, Harding B, Cameron D, Pannett AA, Höög A, Heath H, James-Newton LA, Robinson B, Zarbo RJ, Cavaco BM, Wassif W, Perrier ND, Rosen IB, Kristoffersson U, Turnpenny PD, Farnebo LO, Besser GM, Jackson CE, Morreau H, Trent JM, Thakker RV, Marx SJ, Teh BT, Larsson C, Hobbs MR. HRPT2, encoding parafibromin, is mutated in hyperparathyroidism-jaw tumor syndrome. Nat Genet 2002;32(4):676–80. Epub 2002 Nov 18.
9. DeLellis RA. Parathyroid carcinoma: an overview. Adv Anat Pathol 2005;12(2):53–61. Review.
10. Sharretts JM, Simonds WF. Clinical and molecular genetics of parathyroid neoplazma. Best Pract Res Clin Endocrinol Metab 2010;24(3):491–502. Review.
11. Christmas TJ, Chapple CR, Noble JG, Milroy EJ, Cowie AG. Hyperparathyroidism after neck irradiation. Br J Surg 1988; 75(9):873–4.
12. Adámek S, Libánský P, Naňka O, Šedý J, Pafko P. Surgical Therapy of Primary Hyperparathyroidism and it’s Complications. Experience with 453 Patients. Zentralbl Chir 2005;130:109–113.
13. Adámek S, Beneš E, Naňka O. Epidemiologie a etiologie primární hyperparathyreózy. In Primární hyperparathyreóza, Praha, Galén 2006:202.
14. Harari A, Waring A, Fernandez-Ranvier G, Hwang J, Suh I, Mitmaker E, Shen W, Gosnell J, Duh QY, Clark O. Parathyroid carcinoma: a 43-year outcome and survival analysis. J Clin Endocrinol Metab 2011;96(12):3679-86. Epub 2011 Sep 21.
15. Goldfarb M, O’Neal P, Shih JL, Hartzband P, Connolly J, Hasselgren PO. Synchronous parathyroid carcinoma, parathyroid adenoma, and papillary thyroid carcinoma in a patient with severe and long-standing hyperparathyroidism. Endocr Pract 2009; 15(5):463–8.
16. Shane E. Clinical review 122: parathyroid carcinoma. The Journal of Clinical Endocrinology & Metabolism 2001; 86:485–493
17. Kulkarni PS, Parikh PM. The carcinoma of parathyroid gland. Indian J Cancer 2004;41(2):51–9.
18. Wei CH, Harari A. Parathyroid carcinoma: update and guidelines for management. Curr Treat Options Oncol 2012;13(1):11–23. doi:10.1007/s11864-011-0171-3.
19. Kebebew E, Arici C, Duh QY, Clark OH. Localization and reoperation results for persistent and recurrent parathyroid carcinoma. Arch Surg 2001;136(8):878–85.
20. Agarwal G, Dhingra S, Mishra SK, Krishnani N. Implantation of parathyroid carcinoma along fine needle aspiration track. Langenbecks Arch Surg 2006;391(6):623–6.
21. Libánský P, Broulík P, Křížová H, Naňka O, Pozniak J, Šedý J. The role of preoperative and postoperative localization methods in primary hyperparathyroidism. DMEV 2006;2:78–82.
22. Smith JF, Coombs RR. Histological diagnosis of carcinoma of the parathyroid gland. J Clin Pathol 1984;37(12):1370–8.
23. Thompson LD. Parathyroid carcinoma. Ear Nose Throat J 2009;88(1):722–4.
24. Chiofalo MG, Scognamiglio F, Losito S, Lastoria S, Marone U, Pezzullo L. Huge parathyroid carcinoma: clinical considerations and literature review. World J Surg Oncol 2005;3:39.
25. Sobin LH. TNM klasifikace zhoubných novotvarů. 7. vydání. Praha, Ústav zdravotnických informací a statistiky České republiky 2011:88–92. ISBN 978-80-904259-6-5.
26. Owen RP, Silver CE, Pellitteri PK, Shaha AR, Devaney KO, Werner JA, Rinaldo A, Ferlito A. Parathyroid carcinoma: a review. Head Neck 2011;33(3):429–36. doi: 10.1002/hed.21376. Review. No abstract available.
27. Ippolito G, Palazzo FF, Sebag F, De Micco C, Henry JF. Intraoperative diagnosis and treatment of parathyroid cancer and atypical parathyroid adenoma. Br J Surg 2007;94(5):566–70.
28. Solórzano CC, Carneiro-Pla DM, Lew JI, Rodgers SE, Montano R, Irvin GL. Intra-operative parathyroid hormone monitoring in patients with parathyroid cancer. Ann Surg Oncol 2007; 14(11):3216–22. Epub 2007 Sep 6.
29. Dudešek B, Gatěk J, Duben J, Bakala J, Hnátek L, Hasa E, Musil T. Mini-invasive radiation-navigated parathyreoidectomy – MIRP. Rozhl Chir 2004;10:498–502.
30. Digonnet A, Carlier A, Willemse E, Quiriny M, Dekeyser C, de Saint Aubain N, Lemort M, Andry G. Parathyroid carcinoma: a review with three illustrative cases. J Cancer 2011;2:532–7. Epub 2011 Oct 27.
31. Bukowski RM, Sheeler L, Cunningham J, Esselstyn C. Successful combination chemotherapy for metastatic parathyroid carcinoma. Arch Intern Med 1984;144(2):399–400.
32. Betea D, Bradwell AR, Harvey TC, Mead GP, Schmidt-Gayk H, Ghaye B, Daly AF, Beckers A. Hormonal and biochemical normalization and tumor shrinkage induced by anti-parathyroid hormone immunotherapy in a patient with metastatic parathyroid carcinoma. J Clin Endocrinol Metab 2004;89(7):3413–20.
33. Sandelin K, Auer G, Bondeson L, Grimelius L, Farnebo LO. Prognostic factors in parathyroid cancer: a review of 95 cases. World J Surg 1992;16:724–31.
34. Givi B, Shah JP. Parathyroid carcinoma. Clin Oncol (R Coll Radiol). 2010;22(6):498–507. Epub 2010 May 26.
35. Silverberg SJ, Rubin MR, Faiman C, Peacock M, Shoback DM, Smallridge RC, Schwanauer LE, Olson KA, Klassen P, Bilezikian JP. Cinacalcet hydrochloride reduces the serum calcium concentration in inoperable parathyroid carcinoma. J Clin Endocrinol Metab 2007;92(10):3803–8. Epub 2007 Jul 31.
36. Captur G, Grimaud LM, Betts A, Degaetano J, Attard A, Vassallo J. Parathyroid carcinoma: clinical course, diagnosis and management. Malta Med J 2010;22:25–30.
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