Importance of PET for Diagnostics of Persistence of Neck Metastases after Therapy Under the Salvage Protocol in Advanced Head and Neck Carcinomas

Czech version

Authors: Z. Horáková; E. Tóthová
Authors‘ workplace: Klinika otorinolaryngologie a chirurgie hlavy a krku LF MU a FN, Brno přednosta prof. MUDr. R. Kostřica, CSc.
Published in: Otorinolaryngol Foniatr, 57, 2008, No. 4, pp. 213-217.
Category: Original Article

Overview

In organ preservation protocols the management of neck dissection is still unclear. There is no suitable tool for exclusion of neck metastases persistence. On our group of patients we have assessed the value of PET and CT diagnostics. Our PET results showed high specificity and high positive predictive value. Relatively low negative predictive value did not confirm the possibility for PET being a tool for indication of neck dissection.

Key words:
PET, organ preservation protocol, head and neck cancer, lymphadenopathy, neck metastasis.

Sources

1. Adams, S., Baum, R.: Prospective comparison of PET with conventional imaging modalities. Eur J. Nucl. Med., roč. 25, 1998, s. 1255-1260.

2. Allal, A., Dulguerov, P.: A conservation approach to pharyngeal carcinoma with advanced neck disease: optimizing neck management. Head Neck, 21, 1999, s. 217-222.

3. van der Breckel, M., Stel, H.: Cervical lymph node metastases assessment of radiologic criteria. Radiology, roč., 177, 1990, s. 379-384.

4. Brize, D., Prosnitz, R., Hunter, S.: Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head and neck cancer. Int. J. Radiation Oncology, 58, 2004, s. 1418-1423.

5. Brkovich, V., Miller, F., Kanad, A.: The role of PET in the management of the N-positive neck in head and neck squamous cell carcinoma after chemoradiotherapy. Laryngoscope, 116, 2006, s. 855-858.

6. Frank, D., Hu, K.: Planned neck dissection after concomitant radiochemotherapy for advanced head and neck cancer. Laryngoscope, 115, 2005, s. 1015-1021.

7. Greven, K., Williams, D.: Serial positron emission tomography scan following radiation therapy. Head Neck, 23, 2001, s. 942-946.

8. Lowe, J., Boyd, J., Dunphy, F.: Surveillance for recurrent head and neck cancer using PET. J. Clinical. Oncology, 18, 2000, s. 651-658.

9. McHam, S., Adelstein, D., Rybicki, L.: Who merits a neck dissection after definitive chemoradiotherapy. Head Neck, 25, 2003, s. 2003-2008.

10. Mendenhall, W., Villaret, D., Amur, R.: Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck, 24, 2002, s. 1012-1018.

11. Narayan, K., Crane, C.: Planned neck dissection as an adjunkt to the management of patiens with advanced neck disease with definitive radiotherapy: for some or for all? Head Neck, 21, 1999, s., 606-613.

12. Nayak, J., Walvekar, R., Andrade, R., Daamen, N.: Deferring planned neck dissection following chemoradiation for stage IV head and neck cancer: the utility of PET-CT. Laryngoscope, 117, 2007, s. 2129-2134.

13. Ojiri, H., Mendenhall, W., Stringer, S.: Post RT CT results as a predictive model for the necessity of planned post RT neck dissection. Int. J. Radiation Oncology, 52, 2002, s. 420-428.

14. Praženica P., Horka P., Navara M., Svárovský J., Mikolaj M., Voldřich Z.: Morfológia a funkci ramena po blokových krčných disekciách šetriacich nervus accessorius. Otorinolaryng. a Foniat. /Prague/, 52, 2003, 4, s. 190-194.

15. Wolf, G.: Options for preserving the larynx in patiens with advanced laryngeal and hypopharyngeal cancer. ENT Journal, 80, 2001, s. 897-902.

16. Yau, M., Smith, R., Graham, M., Hoffman, H.: The role of FCG PET in management of neck metastases from head and neck cancer after definitive radiation treatment. In. J. Radiation Oncology Biol. Phys., 63, 2005, s. 1-9.

17. Zimmer, L., Snyderman, C., Fukui, M.: The use of combined PET/CT for lacalizing recurrent head and neck cancer. ENT Journal, 84, 2005, s. 104-110.