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Histological Investigation of the Temporal Bone in Foetuseswith Trisomy of the 18th Chromosome


Authors: Viktor Chrobok;  E. Šimáková *;  V. Jüttnerová **
Authors‘ workplace: ORL oddělení Nemocnice Pardubice, přednosta prof. MUDr. A. Pellant, DrSc. Fingerlandův ústav patologie FN Hradec Králové, předsnota prof. MUDr. I. Šteiner, CSc. *Oddělení genetiky Fakultní nemocnice Hradec Králové, přednosta MUDr. V. Jüttnerová **
Published in: Otorinolaryngol Foniatr, , 1999, No. 3, pp. 162-164.
Category:

Overview

The authors evaluate histological findings in 17 temporal bones of subjects withtrisomy of the 18th chromosome (Edwards syndrome). In 13 (76 %) temporal bones pathologicalfindings were detected in the area of the external or middle ear. In particular retardation of thewhole ear was involved, stenosis of the external auditory meatus, malformation of the ossicles andof the middle ear and muscles. Changes in the inner ear were diagnosed in 12 (71 %) temporal bones.Pathological findings included a short and wide inner auditory meatus, scala communis, endolym-phatic hydrops, widening of the lateral semicircular canal.The authors compare their observation with data in the literature. In subjects with Edwardssyndrome typical changes in the hearingand vestibular organ cannot be assessed.

Key words:
temporal bone, histology, trisomy 18, Edwards syndrome.

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Labels
Audiology Paediatric ENT ENT (Otorhinolaryngology)

Article was published in

Otorhinolaryngology and Phoniatrics


1999 Issue 3

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