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Development of an in vitro model to study the effect of hyperbaric oxygen therapy on the antimicrobial effects of selected antibiotics


Authors: M. Rozložník 1,2,3;  S. Havliková 1;  J. Kociánová 1;  M. Hájek 1,4;  A. Lochmanová 1,5;  B. Balcarková 1;  J. Kuzma 1;  D. Chmelař 1
Authors‘ workplace: Katedra biomedicínských oborů, Lékařská fakulta Ostravské univerzity, Ostrava, vedoucí katedry prof. MUDr. David Stejskal, Ph. D., MBA 1;  DNB consult, s. r. o, Kežmarok, vedoucí pracoviště Dr. Miroslav Rozložník 2;  DAN Europe Slovensko, město 3;  Městská nemocnice, Ostrava, MUDr. Petr Uhlig 4;  Institut ochrany veřejného zdraví, Ostrava 5
Published in: Pracov. Lék., 70, 2018, No. 3-4, s. 156-158.
Category:

Overview

Bacterial soft tissue infections represent the most common infections. Usually, they are caused by anaerobic, microaerophilic, facultative anaerobic and aerobic bacteria. In pathogenesis, a tissue is initially colonized by aerobic bacteria, which create a suitable environment for secondary colonization of anaerobic bacterial strains. Successful therapy of soft tissues infections consist of appropriate surgery treatment, targeted anti-microbial therapy and application of hyperbaric oxygen therapy (HBOT), i.e. breathing of pure oxygen under elevated ambient pressure. Nowadays, despite a lot of positive clinical evidence of HBOT in soft tissue infection treatment, no valid experimental model is established. The aim of our project was the development of an experimental model to study host-pathogen interaction during HBOT.

Keywords:

HBOT – antibiotics – Bacteria – hyperoxia


Sources

1. Brook, I. Microbiology and management of abdominal infections. Dig Dis Sci., 2008 Oct;53(10):2585–91.

2. Edmiston, C. E., McBain, A. J., Kiernan, M., Leaper D. J. A narrative review of microbial biofilm in postoperative surgical site infections: clinical presentation and treatment. J Wound Care, 2016 Dec 2;25(12):693–702.

3. Signoretto, C., Bianchi, F., Burlacchini, G., Canepari, P. Microbiological evaluation of the effects of hyperbaric oxygen on periodontal disease. New Microbiol., 2007 Oct;30(4):431–437.

4. Devaney, B., Frawley, G., Frawley, L., Pilcher, D. V. Necrotising soft tissue infections: the effect of hyperbaric oxygen on mortality. Anaesth Intensive Care, 2015 Nov;43(6):685–692.

5. Mathieu, D. (ed): Handbook on Hyperbaric Medicine. Springer, Dordrecht 2006, s. 31–48.

Labels
Hygiene and epidemiology Hyperbaric medicine Occupational medicine

Article was published in

Occupational Medicine

Issue 3-4

2018 Issue 3-4

Most read in this issue
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