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Lung cancer risk in workers with acknowledged silicosis in the Czech Republic


Authors: A. Šplíchalová 1,2;  H. Tomášková 1,2;  Z. Jirák 2;  H. Lehocká 1,2;  P. Urban 3;  J. Holub 4;  D. Pelclová 5;  E. Hrnčíř 6;  A. Eichlerová 7;  M. Nakládalová 8;  M. Bartnická 9;  A. Hejlek 10;  L. Adámková 11;  D. Čermáková 12
Authors‘ workplace: Zdravotní ústav se sídlem v Ostravě, ředitel RNDr. Petr Hapala 1;  Ústav fyziologie a patofyziologie, FZS OU, Ostrava, vedoucí prof. MUDr. Zdeněk Jirák, CSc. 2;  Odbor hygieny práce a pracovního lékařství, Státní zdravotní ústav Praha vedoucí odboru doc. MUDr. Pavel Urban, CSc. 3;  Odbor analýz, publikací a externí spolupráce, Ústav zdravotnických informací a statistiky České republiky, vedoucí odboru Mgr. Jiří Holub 4;  Klinika nemocí z povolání Univerzity Karlovy v Praze, 1. lékařské fakulty a Všeobecné fakultní nemocnice v Praze, přednostka prof. MUDr. Daniela Pelclová, CSc. 5;  Klinika pracovního a cestovního lékařství Univerzity Karlovy v Praze, 3. lékařské fakulty a Fakultní nemocnice Královské Vinohrady, přednosta doc. MUDr. Evžen Hrnčíř, CSc., MBA 6;  Centrum pracovního lékařství, Pardubická krajská nemocnice, a. s. primářka MUDr. Alexandra Eichlerová 7;  Klinika pracovního lékařství Lékařské fakulty Univerzity Palackého a Fakultní nemocnice Olomouc, přednostka doc. MUDr. Marie Nakládalová, Ph. D. 8;  Oddělení nemocí z povolání, Nemocnice Podlesí, Třinec, primářka MUDr. Marie Bartnická 9;  Oddělení pracovního lékařství, Nemocnice České Budějovice, primář MUDr. Aleš Hejlek 10;  Privátní odborná lékařka pro pracovní lékařství, Zlín 11;  Oddělení nemocí z povolání, Krajská nemocnice Liberec, primářka MUDr. Dana Čermáková 12
Published in: Pracov. Lék., 62, 2010, No. 1, s. 13-19.
Category: Original Papers

Overview

The aim of this study was to compare lung cancer risk in workers with acknowledged form of silicosis and non-exposed general population of the Czech Republic. The study sample included 797 males registered with silicosis in the National Registry of Occupational Diseases in 1992–2001. The basic data on study sample obtained from the National Registry of Occupational Diseases were combined with data from the National Cancer Registry and the National Population Registry. Carcinogenic risk of the study sample in comparison with Czech male population was evaluated by calculation of Standardized Incidence Ratio ( SIR) in 1992–2006. The average age of the study sample in time of diagnosed silicosis was 60.4 years; the average exposure was 24.2 years. In 1992–2006, 61 workers developed lung cancer. Significantly higher lung cancer risk (SIR = 2.81; 95% CI 2.1–3.6) was confirmed in workers with silicosis compared to the general Czech male population. The highest lung cancer risk was identified in ore-miners and breakers, metal workers, and metallurgist-founders. Significantly higher proportion of lung cancer was found in a group of smokers and ex-smokers in comparison with non-smokers (p < 0.01). No significant relationship was identified either between lung cancer incidence and estimated lifetime exposure to silica dust or between lung cancer incidence and degree of severity of silicosis by the ILO classification in the study sample.

Keywords:
silicosis, lung cancer, silica dioxide, smoking


Sources

1. BROWN, T. Silica exposure, smoking, silicosis and lung cancer – complex interactions. Occup. Med., 2009, 59, s. 89–95.

2. CALVERT, G. M., RICE, F. L., BOIANO, J. M., SHEEHY, J. W., SANDERSON, W. T. Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States. Occup. Environ. Med., 2003, 60 (2), s. 122–129.

3. CARTA, P., ARU, G., MANCA, P. Mortality from lung cancer among silicotic patients in Sardinia: an update study with 10 more years of follow up. Occup. Environ. Med., 2001, 58, s. 786–793.

4. CASSIDY, A., MANNETJE, A., VAN TONGEREN, M., FIELD, J. K., ZARIDZE, D., SZESZENIA-DABROWSKA, N., RUDNAI, P., LISSOWSKA, J., FABIANOVA, E., MATES, D., BENCKO, V., FORETOVA, L., JANOUT, V., FEVOTTE, J., FLETCHER, T., BRENNAN, P., BOFFETTA, P. Occupational exposure to crystalline silica and risk of lung cancer. Epidemiology, 2007, 18 (1), s. 36–43.

5. CHECKOWAY, H., HUGHES, J. M., WEILL, H., SEIXAS, N. S., DEMERS, P. A. Crystalline silica exposure, radiological silicosis, and lung cancer mortality in diatomaceous earth industry workers. Thorax, 1999, 54, s. 56–59.

6. DING, M., CHEN, F., SHI, X., YUCESOY, B., MOSSMAN, B., VALLYATHAN, V. Diseases caused by silica: mechanisms of injury and diseases development. Int. Immunopharmacol., 2002, 2, s. 173–182.

7. DOBIÁŠ, L., GAJDOŠOVÁ, D., ŠRÁM, R. J., JANČA, L., RODA, Š. Risk associated with inhalation of fungal metabolites. In Procceding of the Internat. Conf. on genetic Toxicology of Complex Mixtures. Washington D.C., 1989, s. 37.

8. EINBRODT, H. J. Quantitative und qualitative Untersuchungen über die Staubretention in der menschlichen Lunge. Beitr. Silikose-Forsch., 1965, H. 87, s. 1–105.

9. ERREN, T. C., GLENDE, C. B., MORFELD, P., PIEKARSKI, C. Is exposure to silica associated with lung cancer in the absence of silicosis? A meta-analytical approach to an important public health question. Int. Arch. Occup. Envitron. Health, 2009, 82, s. 997–1004.

10. HAMILTON, R. F. JR, THAKUR, S. A., HOLIAN, A. Silica binding and toxicity in alveolar macrophages. Free Radic. Biol. Med., 2008, 44 (7), s. 1246–1258.

11. HESSEL, P. A., GAMBLE, J. F., NICOLICH, M. Relationship between silicosis and smoking. Scand. J. Work Environ. Health, 2003, 29 (5), s. 329–336.

12. HOFSETH, L. J., WARGOVICH, M. J. Inflammation, cancer and targets of ginseng. J. Nutr., 2007, 137(1 Suppl), s. 183S–185S.

13. International Agency For Research On Cancer: Monographs on the evaluation of carcinogenic risks to humans. Silica, some silicates, coal dust and para-aramid fibrils. Vol 68, IARC, Lyon 1997.

14. KURIHARA, N., WADA, O. Silicosis and smoking strongly increases lung cancer risk in silica-exposed workers. Ind. Health, 2004, 42, s. 303–314.

15. LATZA, U., DEGENS, P., BAUR, X. Lung cancer risk at exposure to dust with content of silica and coal-miner dust. Arbeitsmed. Sozialmed. Umweltmed., 2000, 35, s. 424–438.

16. LIANG, H. Y., LI, X. L., YU, X. S., GUAN, P., YIN, Z. H., HE, Q. C., ZHOU, B. S. Facts and fiction of the relationship between pre-existing tuberculosis and lung cancer risk: a systematic review. Int. J. Cancer, 2009, 125 (12), s. 2936–2944.

17. LYNGE, E., KURPPA, K., KRISTOFERSEN, L., MALKER, H., SAULI, H. Occupational groups potentially exposed to silica dust: a comparative analysis of cancer mortality and incidence based on the Nordic occupational mortality and cancer incidence registers. Lyon: IARC, 1990.

18. MOSHAMMER, H., NEUBERGER, M. Lung cancer and dust exposure: results of a prospective cohort study following 3260 workers for 50 years. Occup. Environ. Med., 2004, 61, s. 157–162.

19. O’BYRNE, K. J., DALGLEISH, A. G. Chronic immune activation and inflammation as the cause of malignancy. Br. J. Cancer, 2001, 85, s. 473–483.

20. PARTANEN, T., JAAKKOLA, J., TECH, L., TOSSAVAINEN, A., TECH, D. Silica, silicosis and cancer in Finland. Scand. J. Work. Environ. Health, 1995, 21, suppl 2, s. 84–6.

21. PELUCCHI, C., PIRA, E., PIOLATTO, G., COGGIOLA, M., CARTA, P., LA VECCHIA, C. Occupational silica exposure and lung cancer risk: a review of epidemiological studies 1996–2005. Annals of Oncology, 2006, 17, s. 1039–1050.

22. SCHEEPERS, P. T., MICKA, V., MUZYKA, V., ANZION, R., DAHMANN, D., POOLE, J., BOS, R. P. Exposure to dust and particle-associated 1-nitropyrene of drivers of diesel-powered equipment in underground mining. Ann. Occup. Hyg., 2003, 47, s. 379–388.

23. SMITH, A. H., LOPIPERO, P. A., BARROGA, V. R. Meta-analysis of studies of lung cancer among Silicotics. Epidemiology, 1995, 6, s. 617–624.

24. STATA (Stata Statistical Software: Release 9.0) [computer program]. Stata Corporation; 2005.

25. STEENLAND, K., MANNETJE, A., BOFFETTA, P., STAYNER, L., ATTFIELD, M., CHEN, J., DOSEMECI, M., DEKLERK, N., HNIZDO, E., KOSKELA, R., CHECKOWAY, H. International Agency for Research on Cancer. Pooled exposure-response analyses and risk assessment for lung cancer in 10 cohorts of silica-exposed workers: an IARC multicentre study. Cancer Causes Control, 2001, 12 (9), s. 773–784.

26. STRAIF, K., BENBRAHIM-TALLAA, L., BAAN, R., GROSSE, Y., SECRETAN, B., EL GHISSASSI, F., BOUVARD, V., GUHA, N., FREEMAN, C., GALICHET, L., COGLIANO, V. WHO International Agency for Research on Cancer Monograph Working Group. A review of human carcinogens-part C: metals, arsenic, dusts, and fibres. Lancet Oncol., 2009, 10 (5), s. 453–454.

27. TOMÁŠKOVÁ, H., JIRÁK, Z., MENZLOVÁ, M., BEŠKA, F., ZAVADILOVÁ, V., CÍMOVÁ, K., BUŽGA, M. Výskyt nádorových onemocnění a posouzení míry karcinogenního rizika u horníků kamenouhelných dolů. Čes. prac. Lék., 2005, č. 4, s. 198–202.

28. TSUDA, T., BABAZONO, A., YAMAMOTO, E., MINO, Y., MATSUOKA, H. A meta-analysis on the relationship between pneumoconiosis and lung cancer. J. Occup. Health, 1997, 39, s. 285–294.

29. ULM, K., EHNES, H., GULDNER, K., KIESER, D., GEREIN, P., EIGENTHALER, J., STEINIG, O., SPECHT, W., NUSS, H., ZOPPELLI, L., SCHMIDT, B. Exposure to respirable dust with content of silica, silicosis and lung cancer – exposure data. Arbeitsmed. Sozialmed. Umveltmed., 2001, 36, s. 273–278.

30. ULM, K., GEREIN, P., EIGENTHALER, J., SCHMIDT, S., EHNES, H Silica, silicosis and lung-cancer: results from a cohort study in the stone and quarry industry. Int. Arch. Occup. Environ. Health, 2004, 77, s. 313–318.

31. ULM, K., WASCHULZIG, B., EHNES, H., GULDNER, K., THOMASSON, B., SCHWEBIG, A., NUSS, H. Silica dust and lung cancer in the German stone, quarrying, and ceramics industries: results of a case-control study. Thorax, 1999, 54, s. 347–351.

32. WOITOWITZ, H. J. Carcinogenic effect of respirable dust with content of silica. Arbeitsmed. Sozialmed. Umveltmed., 1999, 34, s. 524–532.

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