Lung cancer risk in workers with acknowledged silicosis in the Czech Republic
Authors:
A. Šplíchalová 1,2; H. Tomášková 1,2; Z. Jirák 2; H. Lehocká 1,2; P. Urban 3; J. Holub 4; D. Pelclová 5; E. Hrnčíř 6; A. Eichlerová 7; M. Nakládalová 8; M. Bartnická 9; A. Hejlek 10; L. Adámková 11; D. Čermáková 12
Authors‘ workplace:
Zdravotní ústav se sídlem v Ostravě, ředitel RNDr. Petr Hapala
1; Ústav fyziologie a patofyziologie, FZS OU, Ostrava, vedoucí prof. MUDr. Zdeněk Jirák, CSc.
2; Odbor hygieny práce a pracovního lékařství, Státní zdravotní ústav Praha
vedoucí odboru doc. MUDr. Pavel Urban, CSc.
3; Odbor analýz, publikací a externí spolupráce, Ústav zdravotnických informací a statistiky České republiky, vedoucí odboru Mgr. Jiří Holub
4; Klinika nemocí z povolání Univerzity Karlovy v Praze, 1. lékařské fakulty a Všeobecné fakultní
nemocnice v Praze, přednostka prof. MUDr. Daniela Pelclová, CSc.
5; Klinika pracovního a cestovního lékařství Univerzity Karlovy v Praze, 3. lékařské fakulty a Fakultní nemocnice Královské Vinohrady, přednosta doc. MUDr. Evžen Hrnčíř, CSc., MBA
6; Centrum pracovního lékařství, Pardubická krajská nemocnice, a. s.
primářka MUDr. Alexandra Eichlerová
7; Klinika pracovního lékařství Lékařské fakulty Univerzity Palackého a Fakultní nemocnice Olomouc, přednostka doc. MUDr. Marie Nakládalová, Ph. D.
8; Oddělení nemocí z povolání, Nemocnice Podlesí, Třinec, primářka MUDr. Marie Bartnická
9; Oddělení pracovního lékařství, Nemocnice České Budějovice, primář MUDr. Aleš Hejlek
10; Privátní odborná lékařka pro pracovní lékařství, Zlín
11; Oddělení nemocí z povolání, Krajská nemocnice Liberec, primářka MUDr. Dana Čermáková
12
Published in:
Pracov. Lék., 62, 2010, No. 1, s. 13-19.
Category:
Original Papers
Overview
The aim of this study was to compare lung cancer risk in workers with acknowledged form of silicosis and non-exposed general population of the Czech Republic. The study sample included 797 males registered with silicosis in the National Registry of Occupational Diseases in 1992–2001. The basic data on study sample obtained from the National Registry of Occupational Diseases were combined with data from the National Cancer Registry and the National Population Registry. Carcinogenic risk of the study sample in comparison with Czech male population was evaluated by calculation of Standardized Incidence Ratio ( SIR) in 1992–2006. The average age of the study sample in time of diagnosed silicosis was 60.4 years; the average exposure was 24.2 years. In 1992–2006, 61 workers developed lung cancer. Significantly higher lung cancer risk (SIR = 2.81; 95% CI 2.1–3.6) was confirmed in workers with silicosis compared to the general Czech male population. The highest lung cancer risk was identified in ore-miners and breakers, metal workers, and metallurgist-founders. Significantly higher proportion of lung cancer was found in a group of smokers and ex-smokers in comparison with non-smokers (p < 0.01). No significant relationship was identified either between lung cancer incidence and estimated lifetime exposure to silica dust or between lung cancer incidence and degree of severity of silicosis by the ILO classification in the study sample.
Keywords:
silicosis, lung cancer, silica dioxide, smoking
Sources
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Hygiene and epidemiology Hyperbaric medicine Occupational medicineArticle was published in
Occupational Medicine
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