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Changes of Elastase 1 in Faeces of Diabetic Subjects


Authors: Petr Dítě;  T. Tomečková;  Jiří Dolina;  I. Novotný;  J. Prášek;  A. Žáková;  M. Dastych
Authors‘ workplace: Interní/gastroenterologická klinika FN MU, Brno
Published in: Pracov. Lék., , 2001, No. 1, s. 59-61.
Category:

Overview

Diabetes mellitus is associated in some patients with exocrine pancreatic insufficiency. This applies in parti-cular to type 1 diabetics. Examination of the external pancreatic secretion is assessed by pretentious andexpensive tests using stimulation of the gland by enterohormones, because non-invasive tests are not suffici-ently sensitive for evaluation of the external pancreatic secretion if a mild morphological form of pancreatopathy is involved. Based on their own experience with examination of changes of elastase 1 in faeces, wherethe authors proved in 70.0 % a reduction already in medium severe forms of chronic pancreatitis (classificati-on according to ERCP), a group of subjects suffering from type 1 diabetes and type 2 diabetes was examined.The exocrine pancreatic secretion was reduced in 60.0 % of subjects with type 1 diabetes and only in 5.0 %with type 2 diabetes. This result correlated with the C-peptide level and was not affected by the blood sugarlevel at the time. The authors draw attention to the fact that in subjects with type 1 diabetes where evenduring compensation loss of body weight persists, it is important to consider possible exocrine pancreaticinsufficiency and supplement the patients with pancreatic enzymes.

Key words:
diabetes mellitus – elastase 1 – exocrine pancreatic function

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Labels
Hygiene and epidemiology Hyperbaric medicine Occupational medicine
Topics Journals
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