Assessment of liver and its rezidual functional capacity after an extensive resection
Authors:
M. Havel 1,2; A. Vašura 3; V. Dedek 1,2; P. Širůček 1,2; O. Kraft 1,2; G. Havlová 1; P. Vávra 4; M. Vávrová 5; S. Bobková 1; K. Trulíková 1
Authors‘ workplace:
Klinika nukleární medicíny, Fakultní nemocnice Ostrava
1; Katedra zobrazovacích metod, Lékařská fakulta Ostravské univerzity
2; Interní a kardiologická klinika, Fakultní nemocnice Ostrava
3; Chirurgická klinika, Fakultní nemocnice Ostrava a Lékařská fakulta Ostravské univerzity
4; Radiodiagnostický ústav, Fakultní nemocnice Ostrava, ČR
5
Published in:
NuklMed 2023;12:2-8
Category:
Review Article
Overview
Introduction: Extensive resections in liver parenchyma can lead to the liver dysfunction or liver failure due to the insufficient postoperative remnant. Indication process involves direct and indirect methods for the assessment of liver function.
Topic solved: Morphological imaging methods estimate the liver remnant function mainly based on the volume calculations. Laboratory tests asses rather global function and they may not always correlate with the patient’s prognosis. Scintigraphic methods include monitoring of accumulation of iminodiacetic acid derivatives (IDA), especially determination of hepatic extraction fraction (HEF) and calculation of IDA uptake rate in liver parenchyma.
Conclusion: Scintigraphic methods can be used for the estimation of the liver remnant function during the indication for the extensive liver resections. Especially the calculation of IDA uptake rate in liver parenchyma is potent to identify patients in a higher risk of future liver failure.
Keywords:
function – resection – scintigraphy – liver – IDA
Sources
- Van Den Broek MAJ, Olde Damink SWM, Dejong CHC, et al. Liver failure after partial hepatic resection: definition, pathophysiology, risk factors and treatment. Liver Int. 2008;28:767-780
- de Santibañes E, Alvarez FA, Ardiles V. How to Avoid Postoperative Liver Failure: A Novel Method. World J Surg. 2012;36:125-128
- Olthof PB, Tomassini F, Huespe PE, et al. Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy: Liver volume overestimates liver function. Surgery. 2017;162:775-783
- Bozic D, Podrug K, Mikolasevic I, et al. Ultrasound Methods for the Assessment of Liver Steatosis: A Critical Appraisal. Diagnostics. 2022;12:2287
- Gasperi A De, Mazza E, Prosperi M. Indocyanine green kinetics to assess liver function: Ready for a clinical dynamic assessment in major liver surgery? World J Hepatol. 2016;8:355
- Guerra Ruiz AR, Crespo J, López Martínez RM, et al. Measurement and clinical usefulness of bilirubin in liver disease. Adv Lab Med/Av en Med Lab. 2021;2:352-361
- Šmíd V. Liver fibrosis. Vnitr Lek. 2020;66:61-66
- Rassam F, Olthof PB, Bennink RJ, et al. Current Modalities for the Assessment of Future Remnant Liver Function. Visc Med. 2017;33:442-448
- Lichtinghagen R, Pietsch D, Bantel H, et al. The Enhanced Liver Fibrosis (ELF) score: Normal values, influence factors and proposed cut-off values. J Hepatol. 2013;59:236-242
- Faybik P, Hetz H. Plasma Disappearance Rate of Indocyanine Green in Liver Dysfunction. Transplant Proc. 2006;38:801-802
- Hines RL, Jones SB. Stoelting’s Anesthesia and Co-Existing Disease E-Book. Elsevier Health Sciences; 2021
- Moraes ACO de, Oliveira PC de, Fonseca-Neto OCL da. The impact of the meld score on liver transplant allocation and results: an integrative review. ABCD Arq Bras Cir Dig (São Paulo). 2017; 30:65-68
- Chan Y, Luk W, Cheng L, et al. Tc-99m sulfur colloid SPECT-CT and assessment of functional liver reserve after Y90 radioembolization: A case report. Int J Surg Case Rep. 2019;62:89-93
- Bowen SR, Chapman TR, Borgman J, et al. Measuring total liver function on sulfur colloid SPECT/CT for improved risk stratification and outcome prediction of hepatocellular carcinoma patients. EJNMMI Res. 2016;6:57
- Zuckerman E, Slobodin G, Sabo E, et al. Quantitative liver-spleen scan using single photon emission computerized tomography (SPECT) for assessment of hepatic function in cirrhotic patients. J Hepatol. 2003;39:326-332
- Suzuki Y, Kakisaka K, Sato T, et al. Tc-99m GSA scintigraphy within the first 3 days after admission as an early predictor of outcome in severe acute liver injury. Sci Rep. 2021;11:12518
- Bennink RJ, Dinant S, Erdogan D, et al. Preoperative assessment of postoperative remnant liver function using hepatobiliary scintigraphy. J Nucl Med. 2004;45:965-971
- Howman-Giles R, Moase A, Gaskin K, et al. Hepatobiliary scintigraphy in a pediatric population: determination of hepatic extraction fraction by deconvolution analysis. J Nucl Med. 1993;34: 214-221
- Lieberman DA, Brown PH, Krishnamurthy GT. Improved scintigraphic assessment of severe cholestasis with the hepatic extraction fraction. Dig Dis Sci. 1990;35:1385-1390
- Brown PH, Juni JE, Lieberman DA, et al. Hepatocyte versus biliary disease: a distinction by deconvolutional analysis of technetium-99m IDA time-activity curves. J Nucl Med. 1988;29:623-630
- Prášek J. Atlas Dynamické Cholescintigrafie. 1. vyd. Praha: Agentura Pankrác; 2004, 72 p
- Ekman M, Fjälling M, Friman S, et al. Liver uptake function measured by IODIDA clearance rate in liver transplant patients and healthy volunteers. Nucl Med Commun. 1996;17:235-242
- de Graaf W, van Lienden KP, Dinant S, et al. Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection. J Gastrointest Surg. 2010;14:369-378
- Llovet JM, Kelley RK, Villanueva A, et al. Hepatocellular carcinoma. Nat Rev Dis Prim. 2021;7:6
- Tomášek J, Tuček Š, Andrašina T. Hepatocelulární karcinom–diagnostika a terapie z pohledu klinického onkologa. Gastroenterol a Hepatol Gastroenterol a Hepatol. 2011;3:149-153 [online] [cit. 2022-12-10]. Dostupné na: https://www.prolekare.cz/casopisy/ceska-slovenska-gastro/2011-3-5/hepatocelularni-karcinom-diagnostika-a-terapie-z-pohledu-klinickeho-onkologa-35372
- Reig M, Forner A, Rimola J, et al. BCLC strategy for prognosis prediction and treatment recommendation: The 2022 update. J Hepatol. 2022;76:681-693
- Martin J, Petrillo A, Smyth EC, et al. Colorectal liver metastases: Current management and future perspectives. World J Clin Oncol. 2020;11:761-808
- Rocha FG, Helton WS. Resectability of colorectal liver metastases: an evolving definition. HPB (Oxford). 2012;14:283-284
- Robinson SM, Wilson CH, Burt AD, et al. Chemotherapy-associated liver injury in patients with colorectal liver metastases: a systematic review and meta-analysis. Ann Surg Oncol. 2012;19:4287-4299
- Alvarez FA, Ardiles V, de Santibañes E. The ALPPS Approach for the Management of Colorectal Carcinoma Liver Metastases. Curr Colorectal Cancer Rep. 2013;9:168-177
- Markowicz-Piasecka M, Dębski P, Mikiciuk-Olasik E, et al. Synthesis and Biocompatibility Studies of New Iminodiacetic Acid Derivatives. Molecules. 2017;22:2265
- Chapelle T, Op de Beeck B, Roeyen G, et al. Measuring future liver remnant function prior to hepatectomy may guide the indication for portal vein occlusion and avoid posthepatectomy liver failure: a prospective interventional study. HPB. 2017;19:108-117
- Serenari M, Bonatti C, Zanoni L, et al. The role of hepatobiliary scintigraphy combined with spect/ct in predicting severity of liver failure before major hepatectomy: a single-center pilot study. Updates Surg. 2021;73:197-208
- Wang H, Feng M, Frey KA, et al. Predictive models for regional hepatic function based on 99mTc-IDA SPECT and local radiation dose for physiologic adaptive radiation therapy. Int J Radiat Oncol Biol Phys. 2013;86:1000-1006
- Wang H, Cao Y. Spatially resolved assessment of hepatic function using 99mTc-IDA SPECT. Med Phys. 2013;40:092501
- Nilsson H, Nordell A, Vargas R, et al. Assessment of hepatic extraction fraction and input relative blood flow using dynamic hepatocyte-specific contrast-enhanced MRI. J Magn Reson Imaging. 2009;29:1323-1331
- Papastergiou V, Tsochatzis E, Burroughs AK. Non-invasive assessment of liver fibrosis. Ann Gastroenterol. 2012;25:218-231
Labels
Nuclear medicine Radiodiagnostics RadiotherapyArticle was published in
Nuclear Medicine
2023 Issue 1
Most read in this issue
- Assessment of liver and its rezidual functional capacity after an extensive resection
- Review of the most interesting news and trends of the 35th EANM congress
- Nukleární medicína a MUDr. Ladislav Šabata České Budějovice
- Annual Congress of the European Association of Nuclear Medicine, Barcelona, Španělsko