New method for semiquantitative evaluation of 123I-MIBG in neuroblastoma – calculation of total retention score
Authors:
Igor Černý; Jiří Prášek; Helena Kašpárková
Authors‘ workplace:
Klinika nukleární medicíny, Masarykova Univerzita a FN Brno
Published in:
NuklMed 2014;3:62-66
Category:
Original Article
Overview
Introduction:
Semiquantitative evaluation of 123I-MIBG accumulation in pediatric neuroblastoma make it possible to quantify answer to therapy and to assess prognosis – ability to achieve complete remission. Semiquantitative scores Curie and SIOPEN are mostly used nowadays. Japanese authors introduced a new method in 2012; it is based on the calculation of total retention score (TMRR). We evaluated this method in our department.
Material and methods:
We evaluated retrospectively 10 patients (5 boys, 5 girls, age 0 to 7 years); we performed 20 examinations with time interval of 2 to 12 months between initial and follow-up examination. Planar whole-body images were performed 4 and 24 hours after injection of 123I-MIBG. Total retention score based on total whole body counts was calculated for all images and compared to Curie and SIOPEN scores.
Results:
We detected decline of TMRR (on average 8,11 %) in 6/10 pts. Decline of Curie score was on average 50,76 % and SIOPEN score 56,23 % in these patients. Two pts had increase level of TMRR, effect of therapy was minimal, their finding did not almost change. Last two pts had also increase of TMRR even if Curie and SIOPEN scores declined significantly.
Conclusion:
Based on our resluts we believe that the proposed method calculating total retention score in evaluation of 123I-MIBG accumulation in padiatric neuroblastoma can serve only as a complementary method and cannot replace current semiquantitative methods.
Key words:
neuroblastoma, 123I-MIBG, quantification
Sources
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Nuclear medicine Radiodiagnostics RadiotherapyArticle was published in
Nuclear Medicine
2014 Issue 4
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