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Hemodialyzovaný pacient s karcinomem štítné žlázy léčený 131I


Authors: Pavel Širůček () 1;  Lubomír Mrhač () 2;  Martin Havel () 2;  Gabriela Havlová () 2;  Otakar Kraft () 1;  Šárka Dočkalová () 2;  Renata Olšanská () 3
Authors‘ workplace: Klinika nukleární medicíny, FN Ostrava, Lékařská fakulta Ostravské univerzity 1;  Klinika nukleární medicíny FN Ostrava 2;  Hemodialyzační centrum FN Ostrava 3
Published in: NuklMed 2012;1:48-52
Category: Casuistry

Overview

For patients with differentiated thyroid cancer in end-stage renal failure who require dialysis, treatment with I-131 isotope may be essential. Diagnosis of cancer excludes these patients from the waiting list for kidney transplantation until the 3-5 year remission is reached. As patients with normal renal function eliminate I-131 from the body mainly by the kidneys, the effective half-life of I-131 in patients with renal failure is prolonged. Therefore, therapeutic dose administered should be reduced in order to reduce the radiation burden especially to the red bone marrow. We present a case report of a 48 year old man in end-stage renal failure treated with I-131 for papillary thyroid carcinoma. For this particular patient we reduced the therapeutic dose by 30 %. Hemodialysis was performed after administration of therapeutic doses of I-131 directly in the premises of nuclear medicine clinic. I-131 is dialyzable and after each dialysis residual radiation decreased by 33-67 %. Radiation exposure of hemodialysis center staff was minimal. Dialysis of patient treated with I-131 did not cause contamination of the dialysis unit.

Key words:
hemodialysis, thyroid cancer, treatment with I-131


Sources

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Nuclear medicine Radiodiagnostics Radiotherapy
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