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Preinvasive Lesions in Gynaecology –  Endometrium


Authors: R. Feranec;  L. Mouková;  J. Chovanec
Authors‘ workplace: Oddělení gynekologické onkologie, Masarykův onkologický ústav, Brno
Published in: Klin Onkol 2013; 26(Supplementum): 52-53

Overview

Preinvasive lesions of the endometrium are histopathological and molecular alterations related to high-risk of uterine carcinoma development. Incidence has increasing tendency. Atypical endometrial hyperplasia is the preinvasive lesion of type I endometrial carcinoma, developing under a hyperestrogenic background. Carcinoma in situ of the endometrium is considered to be precursor lesion of type II endometrial carcinoma, first of all uterine serous carcinoma. Hysterectomy and bilateral oophorectomy is the main therapeutical modality in both preinvasive lesions of the endometrium. The hormonal therapy with progestogens is the possibility of fertility sparing approach in treatment of histological findings of atypical endometrial hyperplasia in young women. Even though preinvasive lesions of the endometrium are clearly defined, the possibilities of endometrial cancer screening are markedly limited.

Key words:
preinvasive lesion –  endometrium –  atypic endometrial hyperplasia –  carcinoma in situ of the endometrium

The authors declare they have no potential conflicts of interest concerning drugs, products, or services used in the study.

The Editorial Board declares that the manuscript met the ICMJE “uniform requirements” for biomedical papers.

Submitted:
11. 9. 2013

Accepted:
9. 10. 2013


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Labels
Paediatric gynaecology Paediatric clinical oncology Gynaecology and obstetrics Surgery Clinical oncology
Topics Journals
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