Je obezita a malnutrice u geriatrických pacientů problémem z hlediska dávkování analgetik?
Authors:
Eliška Dvořáčková
Authors‘ workplace:
Pracoviště klinického farmaceuta, Nemocnice Na Františku, Praha
; Oddělení klinické farmacie a farmakologie, Farmakologický ústav 1. LF UK a VFN v Praze
Published in:
Čas. Lék. čes. 2024; 163: 32-37
Category:
Review Articles
Overview
Both obesity and malnutrition in the elderly population are raising concerns. As majority of pharmacokinetic data are obtained from subjects with a healthy weight range in productive age, administration of correct dosing of drugs to obese elderly patients is quite challenging.
All phases of the pharmacokinetics of drugs (absorption, distribution, metabolism and elimination) are potentially affected by the effect of aging but also by obesity or malnutrition. These changes are often potentiated in the case of a combination of obesity and older age. The problem is also that not all drugs are affected in the same way, therefore it is necessary to know the influence of age and obesity on the kinetics of the particular substance being assessed. 50% of seniors suffer from pain at home and up to 80% during hospitalization. In addition to general knowledge about the effect of age but also obesity and malnutrition on the kinetics of drugs, this overview presents the pharmacokinetic changes of analgesics caused by both obesity and malnutrition.
Keywords:
obesity, malnutrition, older people, drug dosage, analgesics, pharmacokinetics
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Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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