#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#
CS
proLékaře.cz / Journals / Journal of Czech Physicians / 2018 - 5

The origin and development of fat droplet and its role in health and illness

Czech version

Authors: Jana Dvořáková 1;  Miroslava Čedíková 2;  Anna Malečková 3,4;  Vlastimil Kulda 1;  Zbyněk Tonar 3;  Dana Müllerová 5
Authors‘ workplace: Ústav lékařské chemie a biochemie LF UK Plzeň 1;  Ústav fyziologie LF UK Plzeň 2;  Ústav histologie a embryologie LF UK Plzeň 3;  Biomedicínské centrum LF UK Plzeň 4;  Ústav hygieny a preventivní medicíny LF UK 5
Published in: Čas. Lék. čes. 2018; 157: 254-262
Category: Review Article

Overview

Lipid droplets are found in most cells, where they are needed for lipid metabolism and energy homeostasis. Their biogenesis is still not entirely described process, in which an organelle with monomolecular layer on the surface originates from two-layer membrane of the smooth endoplasmic reticulum. Large lipid droplets can be formed either by growth or by fusion of smaller lipid droplets. Their basic functions are controlled lipid deposition and lipid metabolism and the protection of the intracellular environment from lipotoxicity. Currently, dysfunction of lipid droplet is associated with a number of diseases such as obesity, cardiometabolic syndrome, tumor and neurodegenerative diseases, lipodystrophy and cachexia.

Keywords:

lipid droplet, adipocyte, endoplasmic reticulum, perilipin, obesity, type 2 diabetes mellitus, lipodystroph

Sources
  1. Fujimoto T, Parton RG. Not just fat: the structure and function of the lipid droplet. Cold Spring Harb Perspect Biol 2011; 3(3), pii: a004838.
  2. Carr RM, Ahima RS. Pathophysiology of lipid droplet proteins in liver diseases. Exp Cell Res 2016; 340: 187–19
  3. Wang H, Lei M, Hsia R et al. Analysis of lipid droplets in cardiac muscle. Methods Cell Biol 2013; 116: 129–149.
  4. Bosma M. Lipid droplet dynamics in skeletal muscle. Exp Cell Res 2016; 340: 180–186.
  5. Puche JE, Saiman Y, Friedman SL. Hepatic stellate cells and liver fibrosis. Compr Physiol 2013; 3: 1473–1492.
  6. Tachibana T, Kusakabe KT, Osaki S et al. Histocytological specificities of adrenal cortex in the New World Monkeys, Aotus lemurinus and Saimiri boliviensis. J Vet Med Sci 2016; 78: 161–165.
  7. Shen W-J, Azhar S, Kraemer FB. Lipid droplets and steroidogenic cells. Exp Cell Res 2016; 340: 209–214.
  8. Niswender GD. Molecular control of luteal secretion of progesterone. Reprod Camb Engl 2002; 123: 333–339.
  9. Mansfield J, Moger J, Green E, et al. Chemically specific imaging and in situ chemical analysis of articular cartilage with stimulated Raman scattering. J Biophotonics 2013; 6: 803–814.
  10. Schneider MR, Zhang S, Li P. Lipid droplets and associated proteins in the skin: Basic research and clinical perspectives. Arch Dermatol Res 2016; 308(1): 1–6.
  11. Russell TD, Schaack J, Orlicky DJ et al. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands. J Cell Sci 2011; 124: 3247–3253.
  12. Welte MA. Fat on the move: intracellular motion of lipid droplets. Biochem Soc Trans 2009; 37: 991–996.
  13. Welte MA. Expanding roles for lipid droplets. Curr Biol 2015; 25: R470–481.
  14. Castranova V, Rabovsky J, Tucker JH et al. The alveolar type II epithelial cell: a multifunctional pneumocyte. Toxicol Appl Pharmacol 1988; 93: 472–483.
  15. Beilstein F, Carrière V, Leturque A et al. Characteristics and functions of lipid droplets and associated proteins in enterocytes. Exp Cell Res 2016; 340: 172–179.
  16. Čedíková M, Kripnerová M, Dvořáková J et al. Mitochondria in white, brown, and beige adipocytes. Stem Cells Int 2016: 6067349.
  17. Wang CW. Lipid droplets, lipophagy, and beyond. Biochim Biophys Acta 2016; 1861: 793–805.
  18. Murphy S, Martin S, Parton RG. Lipid droplet-organelle interactions; sharing the fats. Biochim Biophys Acta 2009; 1791(6): 441–447.
  19. Tauchi-Sato K, Ozeki S, Houjou T et al. The surface of lipid droplets is a phospholipid monolayer with a unique Fatty Acid composition. J Biol Chem 2002; 277: 44507–44512.
  20. Walther TC, Farese RV. The life of lipid droplets. Biochim Biophys Acta 2009; 1791: 459–466.
  21. Penno A, Hackenbroich G, Thiele C. Phospholipids and lipid droplets. Biochim Biophys Acta 2013; 1831(3): 589–594.
  22. Fujimoto T, Ohsaki Y, Cheng J et al. Lipid droplets: a classic organelle with new outfits. Histochem Cell Biol 2008; 130: 263–279.
  23. Wilfling F, Haas JT, Walther TC et al. Lipid droplet biogenesis. Curr Opin Cell Biol 2014; 29: 39–45.
  24. Robenek H, Lorkowski S, Schnoor M, et al. Spatial integration of TIP47 and adipophilin in macrophage lipid bodies. J Biol Chem 2005; 280: 5789–5794.
  25. Czabany T, Wagner A, Zweytick D et al. Structural and biochemical properties of lipid particles from the yeast Saccharomyces cerevisiae. J Biol Chem 2008; 283: 17065–17074.
  26. Wilfling F, Haas JT, Walther TC et al. Lipid droplet biogenesis. Curr Opin Cell Biol 2014; 29: 39–45.
  27. Chen X, Goodman JM. The collaborative work of droplet assembly. Biochim Biophys Acta 2017; 1862: 1205–1211.
  28. Hashemi HF, Goodman JM. The life cycle of lipid droplets. Curr Opin Cell Biol 2015; 33: 119–124.
  29. Gross DA, Zhan C, Silver DL. Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation. Proc Natl Acad Sci U S A 2011; 108: 19581–19586.
  30. Schuldiner M, Bohnert M. A different kind of love – lipid droplet contact sites. Biochim Biophys Acta 2017; 1862: 1188–1196.
  31. Boschi F, Rizzatti V, Zamboni M et al. Models of lipid droplets growth and fission in adipocyte cells. Exp Cell Res 2015; 336: 253–262.
  32. Boström P, Andersson L, Rutberg M et al. SNARE proteins mediate fusion between cytosolic lipid droplets and are implicated in insulin sensitivity. Nat Cell Biol 2007; 9: 1286–1293.
  33. Farese RV, Walther TC. Lipid droplets finally get a little R-E-S-P-E-C-T. Cell 2009; 139: 855–860.
  34. Garcia EJ, Vevea JD, Pon LA. Lipid droplet autophagy during energy mobilization, lipid homeostasis and protein quality control. Front Biosci Landmark Ed 2018; 23: 1552–1563.
  35. Bickel PE, Tansey JT, Welte MA. PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores. Biochim Biophys Acta 2009; 1791: 419–440.
  36. Barbosa AD, Savage DB, Siniossoglou S. Lipid droplet-organelle interactions: emerging roles in lipid metabolism. Curr Opin Cell Biol 2015; 35: 91–97.
  37. Barbosa AD, Siniossoglou S. Function of lipid droplet-organelle interactions in lipid homeostasis. Biochim Biophys Acta 2017; 1864: 1459–1468.
  38. Morak M, Schmidinger H, Riesenhuber G et al. Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) deficiencies affect expression of lipolytic activities in mouse adipose tissues. Mol Cell Proteomics MCP 2012; 11: 1777–1789.
  39. Murphy S, Martin S, Parton RG. Lipid droplet-organelle interactions; sharing the fats. Biochim Biophys Acta 2009; 1791(6): 441–447.
  40. Roingeard P, Melo RCN. Lipid droplet hijacking by intracellular pathogens. Cell Microbiol 2017; 19(1), doi: 10.1111/cmi.12688.
  41. Müllerová D, Pešta M, Dvořáková J et al. Polychlorinated biphenyl 153 in lipid medium modulates differentiation of human adipocytes. Physiol Res 2017; 66: 653–662.
  42. Bozza PT, Viola JPB. Lipid droplets in inflammation and cancer. Prostaglandins Leukot Essent Fatty Acids 2010; 82: 243–250.
  43. Krahmer N, Farese RV, Walther TC. Balancing the fat: lipid droplets and human disease. EMBO Mol Med 2013; 5(7): 973–983.
  44. Bizzari S, Hamzeh AR, Nair P et al. Novel SPG20 mutation in an extended family with Troyer syndrome. Metab Brain Dis 2017; 32(6): 2155–2159.
  45. Tirinato L, Liberale C, Di Franco S et al. Lipid droplets: a new player in colorectal cancer stem cells unveiled by spectroscopic imaging. Stem Cells Dayt Ohio 2015; 33: 35–44.
  46. Abramczyk H, Surmacki J, Kopeć M, et al. The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue. The Analyst 2015; 140: 2224–2235.
  47. Svačina S, Sucharda P, Stránská Z a kol. Perspektivy farmakoterapie obezity. Časopis lékařů českých 2014; 153: 127–130.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Lung cancer
Idiopathic pulmonary fibrosis: Does the time for change of diagnostic and therapeutic recommendations come?
Treatment of tobacco dependence as a standard part of oncology care
Alcohol as an issue of the public health in the Czech Republic: facts and context
Aulus Cornelius Celsus and a regimen
Article was published in

Journal of Czech Physicians

Issue 5
2018 Issue 5
Download issue PDF
Most read in this issue
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#