Stem cells in orthopaedics
Authors:
Pavel Neckař 1; Eva Syková 2
Authors‘ workplace:
Krajská zdravotní a. s., Masarykova nemocnice v Ústí nad Labem, o. z.
1; Institute of Experimental Medicine AS CR, EU Centre of Excellence, Prague, Czech Republic
2
Published in:
Čas. Lék. čes. 2015; 154: 107-109
Category:
Review Article
Overview
Sharing new ideas and approaches is needed to advance basic scientific research as well as the clinical application of stem cells. In this newsletter we present the current knowledge in stem cell research and therapy within the field of orthopaedics, presenting the definitions, types and sources of the stem cells. The second part of this newsletter focuses on the clinical application of stem cells in the therapy of tissues with very limited capacity for self-regeneration; this includes tendons and ligaments, particularly found in rotator cuff rupture. The sever problems associated with articular cartilage repair have lead to the need for the development of clinical research, with the aim of finding efficient clinical applications of stem cell therapy in cartilage defects and osteoarthritis. However in addition to this, such therapy could be used for the regeneration of bone, as in bone defect repair. The clinical outcome of stem cell therapy is a promising option for the treatment of cartilage, bone and tendon defects; however an increased sample size and additional long-term prospective randomised studies are needed to confirm these preliminary results.
Keywords:
stem cells – cartilage – bone marrow stem cells – clinical application
Sources
1. Porada D, Almeida-Porada M. Mesenchymal stem cells as therapeutics and vehicles for gene and drug delivery. Advanced Drug Delivery Reviews 2010; 62(12): 1156–1166.
2. Granero-Molto M, Weis JA, Miga Mi I, et al. Regenerative effects of transplanted mesenchymal stem cells in fracture healing. Stem Cells 2009; 27(8): 1887–1898.
3. Ma PX. Biomimetic materials for tissue engineering. Advanced Drug Delivery Reviews 2008; 60(2): 184–198.
4. Longo UG, Lamberti A, Maffulli N, et al. Tissue engineered biological augmentation for tendon healing: a systematic review. British Medical Bulletin 2011; 98(1): 31–59.
5. Nourissat G, Diop A, Maure N, et al. Mesenchymal stem cell therapy regenerates the native bone-tendon junction after surgical repair in a degenerative rat model. PLoS ONE 2010; 5(8): Article ID e12248.
6. Cypher T, Grossman J. Biological principles of bone graft healing. Journal of Foot and Ankle Surgery 1996; 35(5): 413–417.
7. Fu S, Cheuk Y, Yung S, Rolf Ch, Chan M. Systematic Review of Biological Modulation of Healing in Anterior Cruciate Ligament Reconstruction. Orthopaedic Journal of Sports Medicine 2014; 3(2): 10–19.
8. Hernigou P, Lachaniette ChHF, Delambre J, et al. Biologic augmentation of rotator cuff repair with mesenchymal stem cells during arthroscopy improves healing and prevents further tears: a case-controlled study. Int Orthop 2014 [Epub ahead of print].
9. Chen WH, Lai MT, Wu T, et al. In vitro stage-specific chondrogenesis of mesenchymal stem cells committed to chondrocytes. Arthritis Rheum 2009; 60(2): 450–459. Epub 2009/01/31
10. Sudo K, Kanno M, Miharada K, et al. Mesenchymal progenitors able to differentiate into osteogenic, chondrogenic, and/or adipogenic cells in vitro are present in most primary fibroblast-like populations. Stem Cell 2007; 25(7): 1610–1617.
11. Fortier LA, Potter HG, Rickey EJ, et al. Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with with microfracture in equine model. J Bone Joint Surg Am 2010; 18(10): 1927–1937.
12. Lee KB, Wang VTZ, Chan YH, et al. A novel, minimally-invasive technique of cartilage repair in the human knee using arthroscopic microfracture and injections of mesenchymal stem cells and hyaluronic acid. A prospective comparative study. In press Ann Acad Med Singapore 2012.
13. Giannini S, Buda R, Vannini F, Cavallo M, et al. One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res 2009; 467(12): 3307–3320.
14. Gobbi A, Karnatzikos G, Scotti C, et al. One-step cartilage repair with bone marrow aspirate concentrated cells and collagen matrix in full- thickness knee cartilage lesion. Results at 2 year follow up. Cartilage 2011; 2(3): 286–299.
15. Harris JD, Brophy RH, Siston RA, Flanigan DC. Treatment of chondral defects in the athlete’s knee. Arthroscopy 2010; 26(6): 841–852.
16. Nejadnik H, Choong PC, Tai BC, et al. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocytes implantation: an observed cohort study. Am J Sports Med 2010; 38(6): 1110–1116.
17. Wakitani S, Imoto K, Yamamoto T, et al. Human autologous culture expanded bone marrow mesenchymal cell transplantation for rapair of cartilage defects in osteoarthritic knees. Osteoarthritis Cartilage 2002; 10(3): 199–206.
18. Afrizah H, Yang Z, Hui JH, et al. A comparison between the chondrogenic potential of human bone marrow stem cells (BMSCs) and adipose-derived stem cells (ADSCs) taken from the same donors. Tissue Eng 2007; 13(4): 659–666.
19. Beane OS, Darling EM. Isoloation, characterization and differentiation of stem cells for cartilage regeneration. Ann Biomed Eng 2012; 40(10): 2079–2097.
20. Caplan A, Correa D. The MSC: an injury drugstore. Cell Stem Cell 2011; 8(1): 11–15.
21. Caplan A, Denis JE. Mesenchymal stem cells as trophic mediator. J Cell Biochem 2006; 1(5): 1076–1084.
22. Gnecchi M, Zhang Z, Ni A, et al. Paracrine mechanisms in adult stem cell signaling and therapy. Circ Res 2008; 21(11): 1204–1219.
23. Prockop DJ. Repair of tissues by adult stem/progenitor cells (MSCs): controversies, myths, and changing paradigms. Mol Ther 2009; 17(6): 936–946.
24. Finkemeier CG. Bone-grafting and bone-graft substitutes. Journal of Bone and Joint Surgery: Series A 2002; 84(3): 454–464.
25. Chamberlain G, Fox J, Ashton B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007; 25(11): 2739–2749.
26. Gangji V, Hauzeur JP, Matos C, et al. Treatment of osteonecrosis of the femoral head with implantation of autologous bonemarrow cells. A pilot study. Journal of Bone and Joint Surgery: Series A 2004; 86(6): 1153–1160.
27. Zamzam MM, Abak AA, Bakarman BK. Efficacy of aspiration and autogenous bone marrow injection in the treatment of simple bone cysts. International Orthopaedics 2009; 33(5): 1353–135
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