Significance of TDM, phenotyping and genotyping for the correct drug dosage
Authors:
Milan Grundmann; Ivana Kacířová
Authors‘ workplace:
Ostravská univerzita, Lékařská fakulta a Fakultní nemocnice Ostrava, Ústavy klinické farmakologie
Published in:
Čas. Lék. čes. 2010; 149: 482-487
Category:
Review Article
Overview
Therapeutic drug monitoring is a specific method of clinical pharmacology for monitoring of the therapy using measurement of drug serum concentrations followed by interpretation and good cooperation with clinician. It significantly helps to personalize and rationalize the treatment, to set individualized dosing, to minimize side effects, to decrease mortality and morbidity and to decrease the costs. Phenotyping and genotyping can increase therapeutic drug monitoring on higher level.
Key words:
therapeutic drug monitoring, individualization and personalization of drug dosing, phenotyping, genotyping.
Sources
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
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