Quality of life of Crohn’s disease patients
Authors:
L. Gabalec 1,2; J. Bureš 2; M. Šedová 3; Z. Valenta 3
Authors‘ workplace:
Orlickoústecká nemocnice a. s., Ústí nad Orlicí, Gastroenterologie
1; Univerzita Karlova v Praze, Lékařská fakulta Hradec Králové, II. interní klinika
2; Ústav informatiky AV ČR, v. v. i., Praha, Oddělení medicínské informatiky
3
Published in:
Čas. Lék. čes. 2009; 148: 201-205
Category:
Original Article
Overview
Background.
The assessment of the quality of life in chronic diseases has started to move from clinical studies to practice. The main goal of the project was to assess the quality of life of Crohn’s disease patients from two Czech centres by means of Czech versions of the general World Health Organization Quality of Life – BREF and specific Inflammatory Bowel Disease Questionnaire, to compare the quality of life of patients with an active disease and those in remission and to compare the quality of life with the general Czech population.
Methods and Results.
103 patients with Crohn’s disease underwent a survey performed by means of two Czech versions of quality of life questionnaire. The dataset consisted of 53 men and 50 women; the average age of patients was 42 years. Increased activity was observed in 45 patients; 58 patients were in remission. By means of WHOQOL-BREF, we found the average global score of quality of life and satisfaction with health in our group to be 3.5 (Czech standard 3.8) and 2.8 (Czech standard 3.7), respectively. The results were compared to the Czech standards. A negative influence of disease activity was statistically significant (p < 0.001) in all domains using either of the two questionnaires. Clinical factors such as the use of corticosteroids or immunosuppressives, and the history of surgery influenced some domains.
Conclusions.
The results from our study indicate that the disease activity may have a significant impact on the quality of life in Crohn’s disease patients. A combination of the general and specific questionnaire may identify factors that would otherwise remain unappreciated properly. The quality of life of patients in remission was comparable to that of the general Czech population.
Key words:
Crohn’s disease, quality of life, health–related quality of life, IBDQ,WHOQOL-BREF.
Sources
1. Dragomirecká E, Škoda C. Kvalita života vymezení pojmu, definice a historický vývoj pojmu v sociální psychiatrii. Čes a slov Psychiat 1997; 93: 423–432.
2. Berndtsson IE, Lindholm E, Oresland T, Hulten L. Health-related quality of life and pouch function in continent ileostomy patients: a 30-year perspective. Dis Colon Rectum 2004; 47(12): 2131–2137.
3. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005; 19(Suppl A): 5–36.
4. Guyatt G, Mitchell A, Irvine EJ, Singer J, Williams N, Goodacre R, et al. A new measure of health status for clinical trials in inflammatory bowel disease. Gastroenterology 1989; 96(3): 804–810.
5. Winship DH, Summers RW, Singleton JW, Best WR, Becktel JM, Lenk LF, et al. National Cooperative Crohn’s Disease Study: study design and conduct of the study. Gastroenterology 1979; 77: 829–842.
6. R Development Core Team (2008). A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria, 2008.
7. Greenstein AJ, Lachman P, Sachar DB, Springhorn J, Heimann T, Janowitz HD, et al. Perforating and non-perforating indications for repeated operations in Crohn’s disease: evidence for two clinical forms. Gut 1988; 29(5): 588–592.
8. Gasche C, Scholmerich J, Brynskov J, D’Haens G, Hanauer SB, Irvine EJ, et al. A simple classification of Crohn’s disease: report of the Working Party for the World Congresses of Gastroenterology, Vienna 1998. Inflamm Bowel Dis 2000; 6(1): 8–15.
9. Louis E, Collard A, Oger AF, Degroote E, Aboul Nasr El Yafi FA, Belaiche J. Behaviour of Crohn’s disease according to the Vienna classification: changing pattern over the course of the disease. Gut 2001; 49(6): 777–782.
10. Bureš J, Živný P, Pecharová, H, Rejchrt S, Kopáčová, M, Široký M, Palička V. Kvalita života nemocných léčených úplnou domácí enterální výživou. Diabet Metabol Endokrin Výž 1999; 2: 17–21.
11. Casellas F, Arenas JI, Baudet JS, Fabregas S, Garcia N, Gelabert J, et al. Impairment of health-related quality of life in patients with inflammatory bowel disease: a Spanish multicenter study. Inflamm Bowel Dis 2005; 11(5): 488–496.
12. Gibson PR, Weston AR, Shann A, Florin TH, Lawrance IC, Macrae FA, et al. Relationship between disease severity, quality of life and health-care resource use in a cross-section of Australian patients with Crohn’s disease. J Gastroenterol Hepatol 2007; 22(8): 1306–1312.
13. Irvine EJ. Quality of Life measurement in inflammatory bowel disease. Scand J Gastroenterol Suppl 1993; 199: 36–39.
14. Casellas F, Lopez-Vivancos J, Badia X, Vilaseca J, Malagelada JR. Impact of surgery for Crohn’s disease on health-related quality of life. Am J Gastroenterol 2000; 95(1): 177–182.
15. Andersson P, Olaison G, Bendtsen P, Myrelid P, Sjodahl R. Health related quality of life in Crohn’s proctocolitis does not differ from a general population when in remission. Colorectal Dis 2003; 5(1): 56–62.
16. Bernklev T, Jahnsen J, Lygren I, Henriksen M, Vatn M, Moum B. Health-related quality of life in patients with inflammatory bowel disease measured with the short form36: psychometric assessments and a comparison with general population norms. Inflamm Inflammatory Bowel Dis 2005; 11(10): 909–918.
17. Gabalec L, Bureš J, Šedová M., Valenta Z. Quality of life in Crohn’s disease. Gut 2007; 56(Suppl 3): A138.
18. Haroon N, Aggarwal A, Lawrence A, Agarwal V, Misra R. Impact of rheumatoid arthritis on quality of life. Mod Rheumatol 2007; 17(4): 290–295.
19. Motlová L, Dragomirecká E, Čermák J, Ungrmanová M, Nechutná R, Panochová A, et al. Day Treatment Program for Schizophrenia. The 6-week Follow-up Concerning Psychopathology and Quality of Life. Psychiatrie 2007; 11(Suppl 3): 26–29.
20. Khanna S, Pal H, Pandey RM, Handa R. The relationship between disease activity and quality of life in systemic lupus erythematosus. Rheumatology (Oxford) 2004; 43(12): 1536–1540.
21. Pallis AG, Mouzas IA, Vlachonikolis IG. The inflammatory bowel disease questionnaire: a review of its national validation studies. Inflamm Bowel Dis 2004; 10(3): 261–269.
Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
Journal of Czech Physicians
Most read in this issue
- Contemporary clinical medicine – assurances and uncertainties
- Minimally invasive thyroidectomy
- What is spirituality and how it helps
- Quality of life of Crohn’s disease patients