Long-term Improvement of Fasting Glycaemia after Switching Basal Insulin from NPH to Determir in Children with Type 1 Diabetes: A 1-Year Multicentre Study
Authors:
Z. Šumník 1; J. Venháčová 2; L. Brázdová 3; J. Škvor 4
Authors‘ workplace:
Pediatrická klinika 2. LF UK a FNM, Praha
1; Dětská klinika LF UP a FN, Olomouc
2; Diabetologická ambulance, Nemocnice Milosrdných bratří, Brno
3; Dětská klinika Masarykovy nemocnice, Ústí nad Labem
4
Published in:
Čas. Lék. čes. 2008; 147: 421-425
Category:
Original Article
Overview
Background.
Paper presents an evaluation of diabetes control after switching from NPH insulin to detemir in children with type 1 diabetes.
Methods and Results.
We performed a non-randomized, observational, multicentre study on the first group of children whose treatment switched from NPH to insulin detemir in four centers of paediatric diabetes. A total of 72 children (39 boys and 33 girls) were included in the analysis. The average age at intervention was 10.6 ± 4.7 yrs, the average age at diabetes onset was 6.2 ± 4.3 yrs. Diabetes control was assessed 3 months prior to the switch and subsequently during 3-month intervals.
Results:
Mean HbA1c decreased from 6.9% at baseline to 6.4% after 3 months of detemir therapy (p = 0.0003). However, in the next months we observed a trend for increasing the HbA1c, and no statistically significant difference in HbA1c was observed at the 6, 9 and 12 months visits vs. baseline. Fasting glycaemia decreased significantly after 3 months of treatment with detemir in comparison with the baseline (the mean value of the difference was 2.1 mmol/l, CI 95% 1.5–2.6, p = 1.4*10-10), and this effect was detectable during all the observational period (month 12 vs. baseline 2.6 mmol/l, p < 10-8).
Conclusions.
Switching basal insulin from NPH insulin to detemir resulted in a short-term improvement of HbA1c, and a long-term decreasing of fasting glycaemia.
Key words:
type 1 diabetes, insulin analogues, detemir, NPH insulin, children.
Sources
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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental HygienistArticle was published in
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