Prognostic Impact of Matrix Metalloproteinases 2,9, and 11 in Stromal Cells Stage I Non-small Cell Lung Cancer

Czech version

Authors: P. Dráč; J. Klein ¹; T. Tichý ³; V. Kolek ²; J. Škarda ³
Authors‘ workplace: II. chirurgická klinika FN, Olomouc ; I. chirurgická klinika FN, Olomouc ¹; Klinika tuberkulózy a respiračních nemocí FN, Olomouc ²; Ústav patologie LF UP, Olomouc ³
Published in: Čas. Lék. čes. 2007; 146: 45-47
Category: Original Article

Overview

Background.
Matrix metalloproteinases (MMPs) belong to proteolytic enzymes. Degradation of the cell basement membrane and the extracellular matrix is one of their functions. In malignant tumors they can hypothetically contribute to the invasion and metastasis formation. They are mostly produced by stromal cells (fibroblasts and endothelial cells) as a response to the presence of tumor cells. MMP-2 (gelatinase A), MMP-9 (gelatinase B) and MMP-11 (stromelysin 3) are often mentioned in regard to Non-small Cell Lung Cancer (NSCLC).

Methods and Results.
The relation between the expression of the above-mentioned matrix metalloproteinases in stromal cells and the cancer-related survival in 80 patients after curative resection of NSCLC in stage I according to TNM was studied. The expression of MMP-2 was associated with cancer-related survival but without significant correlation. No correlation was found in MMP-9. There was a statistically near-significant relation between the expression of MMP-11 and cancer-related survival.

Conclusions.
The expression of MMP-11 in stromal cells in surgically treated NSCLC patients in stage I appears useful for evaluation of their prognosis.

Key words:
non-small cell lung cancer, stromal cells, matrix metalloproteinases.

Labels

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Needfulness and Mission of Health Edu

To the Fourties Anniversary of the Pancreatic Transplantation

Lower Dyspeptic Syndrome Recommended Diagnostic and Therapeutic Practice for General Practitioners 2006

Effect of Hypolipidemic Treatment on the Composition of Bile and the Risk or Cholesterol Gallstone Disease

Orthopaedic Treatment of Osteolytic Lesions in Long Bones of Multiple Myeloma Patients

Postoperative Pulmonary Thromboembolism and Nosocomial Pneumonias: Differential Diagnosis

Cardiac Surgery Operations and Their Influence on Serum Level of Antiinflammatory Cytokine Interleukin-10

Cohort of Lymphedema Patients Followed at the Lymphology Centre of the Dermatovenerologcal Clinic of the 2nd Faculty of Medicine University Hospital Na Bulovce Prague in Years 2000 to 2005 A Retrospective Study

The p53 Positivity in Non-tumor Mucosa in Patients with Superficial Urinary Bladder Cancer

HIV/AIDS and Pathology in Blood Count

Incidence of Hiatal Hernias in the Current Endoscopic Praxis

A Rare Complication of Acute Lymphoblastic Leukaemia in Young Patients