Some New Findings in the Pathogenesis of Myeloproliferative Disorders and New Insight into More Effective Treatment

Czech version

Authors: P. Klener
Authors‘ workplace: 1. interní klinika 1. LF UK a VFN a ÚHKT, Praha
Published in: Čas. Lék. čes. 2006; 145: 4-8
Category: Editorial

Overview

Advances in molecular biology and genomics enabled more detailed view on the pathogenesis of myeloproliferative disorders, which are considered to be a diseases of hematopoietic stem cell. The autor provides an brief overview of the genetic alterations, leading to the chronic myeloid leukemia, myelodysplastic syndrome and acute myeloid leukemia. In the second part, molecular targeted therapies that have been developed based on these insights are reviewed. These are particularly methods preventing increased proliferation such as inhibition of tyrosinkinases (imatinib, dasatinib), inhibitions of farnesyltransferase (tipifarnib), inhibition of angiogenesis (bevacizumab, vatalanib), induction of diferentiation (hypomethylating agenents) and induction of apoptosis (bortezomib). More detailed information is given on some novel drugs which are currently in clinical trials.

Key words:
leukemic hematopoiesis, myeloproliferative disorders, novel therapies.

Labels

Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

Principle and Importance of Using the Array CGH in Hematooncology

Acylation Stimulating Protein – Its Role in Control of Metabolism in the Adipose Tissue

High Dose Therapy with Autologous Stem Cell Transplantation in Patients with Hodgkin’s Lymphoma: Long Term Follow-up in Patients Treated in One Center

Importance of Quantitative Evaluation of BCR-ABL Transcripts Using Real-time PCR for Effective Treatment of Chronic Myeloid Leukemia

Significance of Confirmatory Testing of HLA System in Unrelated Haematopoietic Stem Cell Donors

The Use of Quantitative Assessment of Wilms Tumour Gene for Monitoring of Residual Disease in Acute Myeloid Leukemia Patients

Acute Toxicity of High Dose Interstitial Brachytherapy Boost in Prostate Cancer

Familial Haemophagocytic Lymphohistiocytosis Caused by Perforin Deficit Can Be Successfully Treated by Haematopoietic Stem Cell Transplantation – The First Diagnosed Case in the Czech Republic

Hydatic Cysts – Echinococcosis

Abuse of Buprenorphine Becomes a Problem of the Czech Republic

Robotic Surgery

Impact Factor – Good Servant, but a Bad Master