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CD14 (C-159→T) Polymorphism and Levels of C-reactive Protein


Authors: J. A. Hubáček 2;  P. Stávek 2;  J. Piťha 2;  Z. Škodová 1;  R. Poledne 2
Authors‘ workplace: Laboratoř pro výzkum aterosklerózy IKEM, Praha 2Centrum experimentálního výzkumu chorob srdce a cév, Praha 1
Published in: Čas. Lék. čes. 2003; : 174-176
Category:

Overview

Background.
High plasma levels of C-reactive protein (involved in unspecific host defence) have been described asindependent risk factor of atherosclerosis. The possible association has been analysed between the CD14 C-159→Tpolymorphism and plasma level of CRP.Methods and Results.With the PCR and subsequent restriction analysis we have evaluated C-159→T polymorphismin the CD14 gene of 166 representatively selected male Caucasians with known plasma level of CRP. The CRP wasmeasured immunologically. A significantly higher (p 2.19 mg/l (31.9 %, 15 out of 47) has been detected when comparedto the group with plasma level of CRP lower than 2.18 mg/l (11.9 %, 5 out of 42).Conclusions. CD14 C-159→T polymorphism could be the first described genetic marker associated with plasmalevel of C-reactive protein.

Key words:
CD14 receptor, polymorphism, C-reactive protein.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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