The Effects of Germ-Litce and Somatic Mutations of Genes Involved in Chromatin Remodeling

Czech version

Authors: Šmardová; Šmarda
Authors‘ workplace: Masarykův onkologický ústav, Brno (Přírodovědecká fakulta Masarykovy univerzity, Brno
Published in: Čas. Lék. čes. 2002; : 112-117
Category:

Overview

Chromatin remodeling is engaged in basic cell functions as DNA replication, recombination, DNA repair and transcription of genes. Chromatin is remodeled by ATP-dependent chromatin remodeling complexes and protein complexes covalently modifying histones. Germ-line mutations of the genes coding fot proteins which participate in chromatin remodeling cause severe developmental diseases and they increase a risk of cancer development. Somatic mutations and translocations of such genes are associated with cancer development of certain tumors. Chromatin remodeling mechanisms can thus be targeted by special strategy of cancer therapy.

Key words:
chromatin remodeling, Rubinsten-Taybi syndrome, Coffin-Lowry syndrome, Williams syndrome, Rett syndrome, tumor suppressors, cancers, leukemia.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist

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Article was published in

Journal of Czech Physicians

2002 Issue 4

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