#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Serum Phospholipid Fatty Acid Composition and Insulin Action in Type 2 Diabetic Patients


Authors: T. Pelikánová;  L. Kazdová;  Š. Chvojková;  J. Baše
Authors‘ workplace: Centrum diabetologie Institutu klinické a experimentální medicíny, Praha lnstitut postgraduálního vzděláváni ve zdravotnictví, Praha
Published in: Čas. Lék. čes. 2002; : 55-60
Category:

Overview

Background.
A direct relation has been found between the insulin sensitivity and fatty acid (FA) composition of serum and tissue lipids in adult humans. The aim of our study was to confirm the above relation in different groups of type 2 diabetic patients (DM2).Methods and Results. The FA composition of serum phospholipids was measured by gas liquid chromatography at the insulin action during the two-step hyperinsulinemic isoglycemic clamp (1 and 10 mU/kg.min) in a group of 21 netyly diagnosed DM2 subjects (DMN) and in 24 healthy controls (HC). The DMN group consisted of a subgroup of patients treated with hypoglycemic agents (DMH; n=21) and a group treated with the diet only (DMD; n=11). In diabetics, the metabolic clearance rates of glucose at either insulin level (MCRgwsubmax and MCRg,~max) were signi%cantly reduced in comparison with HS (MCRg,~submax - DMN: 5.35±2.7 ml.kg'.miri'; DMH: 5.38±2.17 ml.kg'.miri'; DMD: 5.48±2.35 ml.kg-'.min'; HS: 10.9±3.3 ml.kg'.min:'; ~

Key words:
type 2 diabetes mellitus, insulin resistance, fatty acids, linoleic acid, arachidonic acid

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#