#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

Specialised Genetic Counselling in Hereditary Forms of Malignancy


Authors: V. Krutílková;  M. Havlovicová;  P. Goetz
Authors‘ workplace: Ústav biologie a lékařské genetiky 2. LF UK a FNM, Praha
Published in: Čas. Lék. čes. 2002; : 23-27
Category:

Overview

Five to ten percent of oncological diseases exhibit monogenic mode of inheritance. They occure as a consequenceof the germline mutations of tumor supressor genes and of the genes engaged in reparative processes. Most commonmonogenically determined oncological diseases are: AD form of breast and ovarian cancer, hereditary nonpolyposiscolorectal cancer (HNPCC, Lynch sy.) and familiar adenomatous polyposis (FAP). The aim of the geneticinvestigation is to evaluate whether the index family deals with the hereditary form of tumor predisposition, than, ifpossible, to perform DNA analysis in the family and to propose preventive screening program (methods) for theprobands in risk.

Key words:
hereditary tumor predisposition, DNA analysis, predictive testing, prevention.

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#