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Paired Filtration Dialysis and Free Radicals


Authors: J. Eiselt;  J. Racek 1;  K. Opatrný jr.
Authors‘ workplace: I. interní klinika LF UK a FN, Plzeň Ústav klinické biochemie a laboratorní diagnostiky LF UK a FN, Plzeň
Published in: Čas. Lék. čes. 2001; : 238-241
Category:

Overview

Background.
Extracorporeal dialysis compensating kidney function represents a risk of elevated production of free radicals (FR). Paired filtration dialysis (PFD) is a hemodialysing method used to compensate kidney function. The aim of our work was to study effects of PFD with two types of hemodiafiltres on the activity of free radicals.Method and Results. Group of nine regularly dialysed patients was treated with PFD 1) with demodiafilter SG3, composed of polysulphone high-flux hemodiafilter and hemophane low-flux dialysator, 2) with hemodiafilter SG30, composed of identical hemodiafilter as the above on and of a polysulphone low-flux dialysator. Parameters related to FR were examined before, at 30th minute and at the end of procedure. Plasma concentration of substances reacting with thiobarbiturate acid (TBARS) increased at 30th minute when PFD with SG3 was used (3.24±0,36 versus 3.48±0,31, p

Key words:
hemodialysis, hemodiafiltration, paired filtration dialysis, free radicals, antioxidants, superoxide dismutase, glutathione peroxidase, glutathione, lipid peroxidation, selenium.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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