Metformin Effect in Diabetic Patients Type 1 - The Placebo Controlled Study

Overview

Background.
Metformin is popular for it’s complex mechanism of action in treatment of the type 2. diabetes. The effect in type 1. diabetes is studied less frequently. The aim of our open, prospective, placebo controlled study was to assess the effect of metformin in poorly controlled diabetic patients type 1 with high insulin requirements.Methods and Results. In the group comprised of 19 type 1 diabetic patients the insulin resistance was assessed by hyperinsulinemie euglycemic clamp and indirect calorimetry at the beginning of the study (B), 3 months later when metformin in the dose of 2x850 mg was added to existing insulin therapy (M) and after 3 months of placebo therapy (P). In the same time-intervals the other parameters were measured. Wilcoxon test was used for statistic analysis. All results are given in arithmetic average ± SD. Weight (78.6 ± 17.9; 75.7 ±17.8; 76.8 ± 19.1 kg), Dauly insulin dose (65.4 ± 15.1; 54.4 ± 11.2; 54.8 ± 9.3 IU), HbA1c (8.8 ± 1,8; 8,2 ± 1,1; 10,1 ± 2,8 %), Utilisation of glucose (3.5 ± 1.6; 4.2 ± 1.7; 4.4 ± 1.8 mg/kg/min), triglycerides (1.2 ± 0.5; 1.1 ± 0.4; 1.3 ± 0.7 mmol/l), cholesterol (5.1 ± 0.7; 4.9 ± 0.7; 5.2 ± 0.8 mmol/l).Conclusions. The combination of metformin and the intensive insulin therapy in type 1 diabetic patients led, in contract to placebo, to the significant reduction in weight (p

Key words:
diabetes mellitus type 1, metformin, insulin resistance, euglycemic clamp, indirect calorimetry.