Biological Age Estimation - the Set of Biophysical Tests

Overview

Background.
Biological age is defined as real state of organism with respect to the processes of aging. From thegerontological point of view, the methodology of determination of biological age i s a tool for verification of theories.The role of biological age determination in medicine is wide. It consists. among others in the assessment of theefficiency of anti-aging interventions or in detection of premature aging. Many different batteries of methods forthe measurement of biological age were developed till now. The currently applied methods are not standardized andthey are, as a rule, significantly time-consuming.Methods and Results. The goal of the work was to develop a routine method for biological age determination.Simplicity and reproducibility of measurements was stressed. The result of our work is a set of 7 biophysical methods.Some of the methods are newly developed (measurement of rheological properties of the skin), others are modifiedclassical methods (measurement of accommodation of eye, perception of high frequencies of sound, reaction times).Conclusions. The battery of biophysical test for the routine biological age assessment was developed in ourlaboratory. The information is processed by computer, using multiple linear regression analysis for obtaining thebest assessment of personal biological age. The duration of measurement is roughly 120 min.

Key words:
aging, biological age, battery of tests, biophysics.