#PAGE_PARAMS# #ADS_HEAD_SCRIPTS# #MICRODATA#

CD4+ Lymphopenia and Post-Operative Immunosupression in Cardiac Surgery


Authors: P. Kuneš
Authors‘ workplace: Kardiochirurgická klinika LF UK a FN, Hradec Králové 1 Ústav klinické imunologie a alergologie LF UK a FN, Hradec Králové
Published in: Čas. Lék. čes. 2000; : 361-368
Category:

Overview

The diversity and heterogeneity of biologic reactions is a condition sine qua non for the adaptation of live organismsto changes of external environment. Reactions of the immune system enable survival even in extreme conditions.Modern medicine often reaches situations never met by the organism in phylogenesis. Thanks to up-to-datetherapeutical approaches many patients survive with grave symptoms such as multiple organ failure and extensiveforms of injury. New infectious diseases are emerging, e.g. HIV/AIDS. Notwithstanding the broad array of externalinsults, it becomes obvious that organisms mobilize defence reactions according to a general scheme. Likewise,exhaustion of the immune potential occurs according to an archetypal pattern. In the case of cell-mediated immunitythe faultless course of which is of critical importance for organisms in extreme conditions, the loss begins with theabsence of reactivity of T-cells to specific antigens to end with the absence of their reactivity to polyclonal mitogens.The article deals with pathogenic mechanisms underlying the onset of immunodeficiences caused by both infectiousand non-infectious stimuli with special regard being focused on cardiac surgery in extracorporeal circuit.

Key words:
extracorporeal circuit, surgical trauma, cytokines, mitogens, antigens, Th1/Th2 T-cells, CD4+

Full text is not available online.
If interested in a scan of this journal, contact NTO ČLS JEP.

Labels
Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
Topics Journals
Login
Forgotten password

Enter the email address that you registered with. We will send you instructions on how to set a new password.

Login

Don‘t have an account?  Create new account

#ADS_BOTTOM_SCRIPTS#