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Relationship between the Trace Element Metabolism and the AntioxidantDefence System in Chronic Nephropathies


Authors: Ľ. Podracká;  M. Šašinka;  O. Rácz 1;  A. Šipulová 2;  E. Gayová 3;  M. Horská 4;  A. Böör 5
Authors‘ workplace: Pediatrická klinika LF UPJŠ, Košice, 1 Ústav patologickej fyziológie LF UPJŠ, Košice 2 Ústav experimentálnej medicíny LF UPJŠ, Košice, 3 I. Interná klinika LF UPJŠ, Košice 4 Oddelenie klinickej biochémie FNsP, Košice, 5 Ústav patologickej anatómie LF UPJŠ
Published in: Čas. Lék. čes. 1999; : 337-339
Category:

Overview

Background.
Trace elements - zinc, copper and selenium are part of antioxidant enzymes, superoxide dismutase(SOD) and glutathione peroxidase (GHPx). In renal diseases changes in the trace element metabolism may influencethe equilibrium in the antioxidant defence system and enhance the toxic effect of reactive oxygen molecules.Methods and Results. The authors examined in 53 children with chronic neprophathies (34 with chronicglomerulonephritis, 11 with chronic renal failure and 8 children included in a chronic dialyzation programme) zincand selenium in blood and urine and antioxidant enzymes SOD and GHPx in red blood cells. The lowest SOD activity(737 ± 219 U/g Hb, p < 0.01) and serum zinc concentration (12.9 ± 3.2, p < 0.05) were found in children in theterminal stage of uraemia, GHPx was as compared with the group of healthy children elevated in all groups of sickchildren. In dialysed children GHPx was highest (p < 0.01) and correlated with urinary selenium concentrations(r = -0.86, p < 0.05). The SOD activity depended on the serum copper concentrations (r = 0.78, p < 0.05). The highestrenal zinc and selenium excretion was recorded in patients with glomerulonephritis (p < 0.05).Conclusions. The results support the hypothesis on a causal relationship between trace elements and antioxidantenzymes.

Key words:
SOD, GHPx, zinc, selenium, kidneys, chronic renal failure.

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Addictology Allergology and clinical immunology Angiology Audiology Clinical biochemistry Dermatology & STDs Paediatric gastroenterology Paediatric surgery Paediatric cardiology Paediatric neurology Paediatric ENT Paediatric psychiatry Paediatric rheumatology Diabetology Pharmacy Vascular surgery Pain management Dental Hygienist
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