Krčméry V. (Sr.): Problems of the Antibiotic Resistance

Overview

The authors present a short review of the origin and evolution of antibiotic resistance from the beginning ofantibiotic use. Transferable resistance, i.e. spread of resistance genes by mechanisms of the transduction, conjugationor transposition, plays an important role in the process of the development of resistance in susceptible bacterialstrains. Equally, chromosomally coded resistance is recently becoming relevant. Large selective pressure of theantibiotics lends mutations of genes coding antibiotic resistance. So, bacterial strains produce a large amount ofenzymes, which destroy antibiotic or lose the power for penetration of the antibiotics become completely resistantalso to new antibiotics.

Key words:
antibiotic resistance, transferable resistance, chromosomal resistance.