Postvaccination Immunity after Allogeneic and Autologous Bone Marrow Transplantation

Overview

In the submitted review the author describes time correlation’s of reconstitution of immunity during thepost-transplantation period in patients after autologous and allogeneic bone marrow transplantations. The authorspresents values of different immunological parameters incl. functional examinations of immunity by the method ofblastic lymphocyte transformation after stimulation with mitogens and vaccination antigens during the post-trans-plantation period. She also evaluates mechanisms involved in this process.An illustrative idea on the character and degree of affection of immunity mechanisms after bone marrowtransplantation is provided by the state of postvaccination immunity after immunization made before the diseaseand bone marrow transplantation. The titres of postvaccination antibodies after a 1-4-year interval following bonemarrow transplantation gradually drop to low or zero values. The author emphasises therefore the necessity ofrevaccination of patients with killed vaccines against tetanus, diphtheria, poliovirus and pneumococcal, meningo-coccal and haemophil infection during the post-transplantation period. Recommended vaccination patterns are alsopresented.

Key words:
post-transplantation immunity, postvaccination immunity, killed bacterial and viral vaccines, revac-cination.