Acute kidney injury in patients with cirrhosis – practical summary
Authors:
Kateřina Množil Střídová 1; Soňa Fraňková 2; Jan Šperl 2
Authors‘ workplace:
Interní klinika FNKV a 3. LF UK, Praha
1; Klinika hepatogastroenterologie, Institut klinické a experimentální medicíny, Praha
2
Published in:
Vnitř Lék 2023; 69(5): 299-304
Category:
Main Topic
doi:
https://doi.org/10.36290/vnl.2023.059
Overview
Acute kidney injury (AKI) is a relatively common condition in patients with advanced liver disease and which is associated with increased mortality. It mainly affects patients with decompensated cirrhosis, particularly those with advanced portal hypertension and ascites. The dual organ involvement may have different forms. The contributing pathogenetic mechanisms are common and predict a dismal prognosis. Early diagnosis and interventions involving specialists (in particular, hepatologists and nephrologists) are essential to improve outcomes.
Keywords:
hepatorenal syndrome – liver cirrhosis – therapy – acute kidney injury
Sources
- Teplan V. Posuzování funkce ledvin u pacientů s jaterním onemocněním. Gastroent Hepatol. 2021; 75(2):138-142.
- Merta M. Renální komplikace akutních a chronických onemocnění jater. Gastroent Hepatol. 2019;73(3):250-256.
- Krátká K, Libicherová P, Tesař V, et al. Doporučené postupy ČNS a ČHS JEP pro diagnostiku a léčbu akutního poškození ledvin u jaterní cirhozy. Aktuality v nefrologii. 2021;27(1):7-14.
- Gupta K, Bhurwal A, Law C, et al. Acute kidney injury and hepatorenal syndrome in cirrhosis. World J Gastroenterol. 2021 July 14;27(26):3984-4003.
- Sanyal AJ, Boyer TD, Terrault NA, et al. Zakim and Boyer's hepatology. 7th ed. Elsevier - Health Sciences Division: 2016: 262-280. ISBN 9780323375917
- Bera C, Wong F. Management of hepatorenal syndrome in liver cirrhosis: a recent update. Therap Adv Gastroenterol. 2022;15:17562848221102679.
- European Association for the Study of the Liver. EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis. Journal of Hepatology. 2018;69:406-460.
- Flamm SL, Brown K, Wadei HM, et al. The Current Management of Hepatorenal Syndrome - Acute Kidney Injury in the United States and the Potential of Terlipressin. Liver Transpl. 2021 Aug;27(8):1191-1202.
- Sanchez LO, Francoz C. Global strategy for the diagnosis and management of acute kidney injury in patients with liver cirrhosis. United European Gastroenterol J. 2021 Mar; 9(2):220-228
- Chancharoenthana W, Leelahavanichkul A. Acute kidney injury spectrum in patients with chronic liver disease: Where do we stand? World J Gastroenterol. 2019 July 28; 25(28):3684-3703.
- Møller S, Bendtsen F. The pathophysiology of arterial vasodilatation and hyperdynamic circulation in cirrhosis. Liver International. 2018;38:570-580.
- Nadim MK, Garcia‑Tsao G. Acute Kidney Injury in Patients with Cirrhosis. N Engl J Med. 2023;388:733-45.
Labels
Diabetology Endocrinology Internal medicineArticle was published in
Internal Medicine
2023 Issue 5
Most read in this issue
- Acute kidney injury in patients with cirrhosis – practical summary
- Dyslipidemia – the known unknown
- News in respiratory medicine
- Cardiovascular disease and kidney transplantation