Initial use of subcutaneous plasma-derived C1 inhibitor in prophylaxis of acute attacks of hereditary angioedema in pregnant patients in Slovakia

Czech version

Authors: Katarína Hrubišková ¹; Miloš Jeseňák ^2,3; Juraj Payer ¹
Authors‘ workplace: Centrum pre hereditárny angioedém – Expertízne pracovisko MZ SR pre zriedkavé choroby, V. interná klinika Lekárskej fakulty Univerzity Komenského a Univerzitnej nemocnice Bratislava ¹; Centrum pre hereditárny angioedém – Expertízne pracovisko MZ SR pre zriedkavé choroby, Klinika detí a dorastu, Klinika pneumológie a ftizeológie, Jesseniova lekárska fakulta v Martine, Univerzita Komenského v Bratislave, Univerzitná nemocnica Martin ²; Oddelenie klinickej imunológie a alergológie, Univerzitná nemocnica Martin ³
Published in: Vnitř Lék 2023; 69(4): 265-268
Category: Case reports
doi: https://doi.org/10.36290/vnl.2023.050

Overview

Hereditary angioedema (HAE) is a rare, inborn disease manifested with recurrent attacks of angioedema. They can affect the skin and subcutaneous tissue, mucous membranes (gastrointestinal, respiratory, and uropoietic tracts), and submucous tissue. Women in reproductive age require specific management of the disease regarding both the course of the disease and treatment options. It is not only the treatment in female patients that is specific, but also the situations (pregnancy, breastfeeding). We present a case report of the initial use of a subcutaneous C1 inhibitor in the long-term prophylaxis of HAE attacks in two pregnant patients.

Keywords:

hereditary angioedema – Prophylaxis – pregnancy

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