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Pancytopenia as the main manifestation of human immunodeficiency virus infection in the AIDS stage The authors present a case


Authors: Pavel Polák 1,2,3,4;  Leoš Křen 2,4,5;  Jana Lindušková 6;  Andrea Pavlíková 7;  Michael Doubek 3,4;  Markéta Šejnohová 3;  Miroslav Penka 1,2,3,4
Authors‘ workplace: Oddělení klinické hematologie, Fakultní nemocnice Brno 1;  Katedra laboratorních metod, Fakultní nemocnice Brno 2;  Interní hematologická a onkologická klinika, Fakultní nemocnice Brno 3;  Lékařská fakulta Masarykovy univerzity Brno 4;  Ústav patologie, Fakultní nemocnice Brno 5;  Oddělení klinické mikrobiologie a imunologie, Fakultní nemocnice Brno 6;  Národní referenční laboratoř pro HIV/AIDS, Státní zdravotní ústav, Praha 7
Published in: Vnitř Lék 2021; 67(E-4): 26-28
Category: Case Report

Overview

The authors present a case report of 59-years-old woman examined for pancytopenia recently diagnosed during hospitalization for bilateral interstitial pneumonia without any confirmed etiological agents. Concomitantly, some systemic symptoms like lack of appetite and weight loss were present. Primary hematological disease was ruled out. Positivity of serological screening for HIV-1,2 was rather surprising. Absolute count of CD4+ lymphocytes was 8/μl. Thus, HIV infection was already in stage of AIDS and retrospectively, the interstitial pneumonia has to be judged as AIDS-indicative illness.

Keywords:

pancytopenia – HIV – interstitial pneumonia


Sources

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3. http://szu.cz/uploads/documents/CeM/HIV_AIDS/rocni_zpravy/2019/Grafy_k_ tiskove_zprave_NRL_pro_HIV_AIDS_Trendy_vyvoje_a_vyskyt_HIV_AIDS_v_CR_v_ roce_2019.pdf.

4. European Centre for Disease Prevention and Control, WHO Regional Office for Europe. HIV/AIDS surveillance in Europe 2019 – 2018 data. Stockholm: ECDC; 2019. Dostupné z: https://www.ecdc.europa.eu/en/publications-data/hivaids-surveillance-europe- -2019–2018-data.

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9. Jou E, Gligich O, Chan AC et al. Retrospective study of the prevalence and progression of monoclonal gammopathy in HIV positive versus HIV negative patients. Hematol Oncol 2017; 35(1): 64–68. doi: 10.1002/hon.2247. Epub 2015 Jul 24.

10. Jou E, Gligich O, Chan ACY et al. Viral co-infections and paraproteins in HIV: effect on development of hematological malignancies. Ann Hematol 2016; 95(4): 575–580. doi: 10.1007/s00277–016–2588-z.

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