SGLT2 inhibitors – a new pillar for the treatment of heart failure

Czech version

Authors: Dominika Tavačová; Jan Václavík
Authors‘ workplace: Interní a kardiologická klinika, Fakultní nemocnice Ostrava a Lékařská fakulta Ostravské univerzity, Ostrava
Published in: Vnitř Lék 2021; 67(8): 475-478
Category: Review Articles

Overview

DAPA-HF and EMPEROR-REDUCED clinical trials have shown significant benefits of dapagliflozin and empagliflozin in the treatment of heart failure with reduced ejection fraction regardless of the presence or absence of diabetes mellitus. Their results support the implementation of SGLT2 inhibitors into clinical practice in patients with heart failure, due to their efficacy, safety, and minimal side effects. Their mechanism of action does not depend on the state of neurohumoral activation and SGLT2 inhibitors have a simple dosing regimen, without the need for dose titration. In addition to cardioprotective properties, SGLT2 inhibitors also have a very significant nephroprotective effect. Empagliflozin and dapagliflozin have recently been approved by regulatory authorities for the treatment of adults with symptomatic chronic heart failure with reduced ejection fraction and are becoming one of the basic pillars of treatment for these patients.

Keywords:

dapagliflozin – empagliflozin – heart failure - gliflozins – STLT2 inhibitors

Sources

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Article was published in

Internal Medicine

2021 Issue 8